Literature DB >> 22594332

Adipose-derived mesenchymal stromal cells for chronic myocardial ischemia (MyStromalCell Trial): study design.

Abbas Ali Qayyum1, Mandana Haack-Sørensen, Anders Bruun Mathiasen, Erik Jørgensen, Annette Ekblond, Jens Kastrup.   

Abstract

Adipose tissue represents an abundant, accessible source of multipotent adipose-derived stromal cells (ADSCs). Animal studies have suggested that ADSCs have the potential to differentiate in vivo into endothelial cells and cardiomyocytes. This makes ADSCs a promising new cell source for regenerative therapy to replace injured tissue by creating new blood vessels and cardiomyocytes in patients with chronic ischemic heart disease. The aim of this special report is to review the present preclinical data leading to clinical stem cell therapy using ADSCs in patients with ischemic heart disease. In addition, we give an introduction to the first-in-man clinical trial, MyStromalCell Trial, which is a prospective, randomized, double-blind, placebo-controlled study using culture-expanded ADSCs obtained from adipose-derived cells from abdominal adipose tissue and stimulated with VEGF-A(165) the week before treatment.

Entities:  

Mesh：

Year:  2012        PMID： 22594332     DOI： 10.2217/rme.12.17

Source DB:  PubMed          Journal:  Regen Med        ISSN： 1746-0751            Impact factor:   3.806


  37 in total

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Review 8.  Application of adipose-derived stem cells in heart disease.

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9.  Comparative Analysis of Media and Supplements on Initiation and Expansion of Adipose-Derived Stem Cells.

Authors:  Simone Riis; Frederik Mølgaard Nielsen; Cristian Pablo Pennisi; Vladimir Zachar; Trine Fink
Journal:  Stem Cells Transl Med       Date:  2016-02-02       Impact factor: 6.940

10.  Biological and clinical availability of adipose-derived stem cells for pelvic dead space repair.

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Journal:  Stem Cells Transl Med       Date:  2012-10-23       Impact factor: 6.940
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