Literature DB >> 225940

Pathological actin in vestibular hair cells of the waltzing guinea pig.

A Flock, H Cheung, J Wersäll.   

Abstract

Vestibular type 1 hair cells in the waltzing guinea pig contain needle-shaped inclusion bodies which grow in an uncontrolled fashion associated with the destruction of the cell. The needles are shown to be composed by filaments of actin, a protein identified in the electron microscope by its ability to bind subfragment 1 of myosin. Whereas actin filaments in stereocilia are oriented down towards the cell body, filaments in the needles point up towards the cuticular plate. The hereditary lesion appears to be associated with a defective control of polymerization of actin into filaments.

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Year:  1979        PMID： 225940     DOI： 10.1159/000402911

Source DB:  PubMed          Journal:  Adv Otorhinolaryngol        ISSN： 0065-3071


  6 in total

1.  Vestibular hair cell pathology in the Shaker-2 mouse.

Authors:  M Anniko; A Sobin; J Wersäll
Journal:  Arch Otorhinolaryngol       Date:  1980

2.  Organ of Corti-specific polypeptides: OCP-I and OCP-II.

Authors:  I Thalmann; H L Rosenthal; B W Moore; R Thalmann
Journal:  Arch Otorhinolaryngol       Date:  1980

3.  Auditory hair cell-specific deletion of p27Kip1 in postnatal mice promotes cell-autonomous generation of new hair cells and normal hearing.

Authors:  Bradley J Walters; Zhiyong Liu; Mark Crabtree; Emily Coak; Brandon C Cox; Jian Zuo
Journal:  J Neurosci       Date:  2014-11-19       Impact factor: 6.167

4.  Hair bundle defects and loss of function in the vestibular end organs of mice lacking the receptor-like inositol lipid phosphatase PTPRQ.

Authors:  Richard J Goodyear; Sherri M Jones; Louise Sharifi; Andy Forge; Guy P Richardson
Journal:  J Neurosci       Date:  2012-02-22       Impact factor: 6.167

5.  Rods of actin filaments in type I hair cells of the Shaker-2 mouse.

Authors:  A Sobin; M Anniko; A Flock
Journal:  Arch Otorhinolaryngol       Date:  1982

6.  Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice.

Authors:  Stephanie A Bucks; Brandon C Cox; Brittany A Vlosich; James P Manning; Tot B Nguyen; Jennifer S Stone
Journal:  Elife       Date:  2017-03-06       Impact factor: 8.140
  6 in total

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