Literature DB >> 22593598

Prognostic value of indeterminate IFN-γ release assay results in HIV-1 infection.

Maximilian C Aichelburg1, Julia Tittes, Florian Breitenecker, Thomas Reiberger, Norbert Kohrgruber, Armin Rieger.   

Abstract

In this prospective, longitudinal study on 948 HIV-1-infected patients, subjects with an indeterminate IFN-γ (gamma interferon) release assay (IGRA) result at baseline were at significantly higher risk of developing AIDS-defining manifestations other than tuberculosis (TB) irrespective of CD4(+) T cell count. Thus, in HIV-1-infected patients with advanced quantitative CD4(+) T cell depletion, an indeterminate IGRA might indicate an additional loss of global T cell function, warranting detailed clinical evaluation and careful follow-up.

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Year:  2012        PMID： 22593598      PMCID： PMC3421503          DOI： 10.1128/JCM.01054-12

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  9 in total

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6.  Detection and prediction of active tuberculosis disease by a whole-blood interferon-gamma release assay in HIV-1-infected individuals.

Authors:  Maximilian C Aichelburg; Armin Rieger; Florian Breitenecker; Katharina Pfistershammer; Julia Tittes; Stephanie Eltz; Alexander C Aichelburg; Georg Stingl; Athanasios Makristathis; Norbert Kohrgruber
Journal:  Clin Infect Dis       Date:  2009-04-01       Impact factor: 9.079

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Review 8.  Predictive value of interferon-γ release assays for incident active tuberculosis: a systematic review and meta-analysis.

Authors:  Molebogeng X Rangaka; Katalin A Wilkinson; Judith R Glynn; Daphne Ling; Dick Menzies; Judith Mwansa-Kambafwile; Katherine Fielding; Robert J Wilkinson; Madhukar Pai
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1.  IGRA testing in patients with immune-mediated inflammatory diseases: which factors influence the results?

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2.  Risk factors associated with indeterminate gamma interferon responses in the assessment of latent tuberculosis infection in a high-incidence environment.

Authors:  Tolu Oni; Hannah P Gideon; Nonzwakazi Bangani; Relebohile Tsekela; Ronnett Seldon; Kathryn Wood; Katalin A Wilkinson; Rene T Goliath; Tom H M Ottenhoff; Robert J Wilkinson
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3.  Analysis of predictors influencing indeterminate whole-blood interferon-gamma release assay results in patients with rheumatic diseases.

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4.  Neutrophil-to-Lymphocyte Ratio Is Associated with Impaired Interferon-Gamma Release to Phytohemagglutinin.

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5.  Evaluating an Education Program to Reduce Indeterminate QuantiFERON Gold In-Tube Results.

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6.  Association of CMV-Specific T Cell-Mediated Immunity with CMV DNAemia and Development of CMV Disease in HIV-1-Infected Individuals.

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8.  Interferon-gamma release assay versus tuberculin skin test for latent tuberculosis infection among HIV patients in Brazil.

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  8 in total

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