BACKGROUND/AIM: Since microRNAs (miRNAs) act as translational regulators of multiple genes, single nucleotide polymorphisms (SNP) in them can have potentially wide-ranging effects. Using an association approach, this research examined the effects of the rs6505162 SNP, an A > C polymorphism located in the pre-miRNA region of miR-423, on breast cancer development. MATERIALS AND METHODS: Caucasian Australian women with breast cancer and controls matched for age and ethnicity were genotyped for rs6505162 and their genotypic and allelic frequencies analysed for significant differences. RESULTS: Analysis indicated that there were significant differences between the case and control populations (χ2 = 6.70, p = 0.035), with the CC genotype conferring reduced risk of breast cancer development (odds ratio = 0.50 95% confidence interval = 0.27-0.92, p = 0.03). CONCLUSION: Further functional research is required to determine the mechanism of action of this SNP on miRNA function.
BACKGROUND/AIM: Since microRNAs (miRNAs) act as translational regulators of multiple genes, single nucleotide polymorphisms (SNP) in them can have potentially wide-ranging effects. Using an association approach, this research examined the effects of the rs6505162 SNP, an A > C polymorphism located in the pre-miRNA region of miR-423, on breast cancer development. MATERIALS AND METHODS: Caucasian Australian women with breast cancer and controls matched for age and ethnicity were genotyped for rs6505162 and their genotypic and allelic frequencies analysed for significant differences. RESULTS: Analysis indicated that there were significant differences between the case and control populations (χ2 = 6.70, p = 0.035), with the CC genotype conferring reduced risk of breast cancer development (odds ratio = 0.50 95% confidence interval = 0.27-0.92, p = 0.03). CONCLUSION: Further functional research is required to determine the mechanism of action of this SNP on miRNA function.
Authors: Huanhuan Zhao; Ang Gao; Zhiqian Zhang; Ruoyu Tian; Ang Luo; Mei Li; Dan Zhao; Liya Fu; Li Fu; Jin-Tang Dong; Zhengmao Zhu Journal: Tumour Biol Date: 2015-02-08
Authors: Muhammad Sohail Khan; Bashir Rahman; Taqweem Ul Haq; Fazal Jalil; Bilal Muhammad Khan; Saleh N Maodaa; Saleh A Al-Farraj; Hamed A El-Serehy; Aftab Ali Shah Journal: Genes (Basel) Date: 2021-04-28 Impact factor: 4.096
Authors: Rodolfo Iuliano; Marco Flavio Michele Vismara; Vincenzo Dattilo; Francesco Trapasso; Francesco Baudi; Nicola Perrotti Journal: Biomed Res Int Date: 2013-03-19 Impact factor: 3.411