| Literature DB >> 22592973 |
Chunlei Tang1, Yajuan Liu, Bin Wang, Guolong Gu, Liumeng Yang, Yongtang Zheng, Hai Qian, Wenlong Huang.
Abstract
In an attempt to develop potent anti-HIV drugs, 20 andrographolide derivatives were designed, synthesized, and evaluated for their in vitro anti-HIV activity. The screening results revealed that five compounds showed potent anti-HIV activities with therapeutic indices (TI) above 10. The most promising compound 6f shows a significant TI close to 34.07, with the potency to be a new lead.Entities:
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Year: 2012 PMID： 22592973 DOI： 10.1002/ardp.201200008
Source DB: PubMed Journal: Arch Pharm (Weinheim) ISSN： 0365-6233 Impact factor: 3.751