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Literature DB >> 22592656

Identification of genes regulated by the EWS/NR4A3 fusion protein in extraskeletal myxoid chondrosarcoma.

Abstract

Approximately 75 % of extraskeletal myxoid chondrosarcoma tumors (EMC) harbor a t(9;22) chromosome translocation generating an EWS/NR4A3 fusion protein that is thought to be instrumental in the tumoral process. Current evidence suggests that one function of the fusion protein is to overexpress target genes. We have generated an in vitro human cellular model in which the fusion protein is expressed in mesenchymal bone marrow stem cells. We have performed microarray analyses of these cells and identified several genes overexpressed in the presence of EWS/NR4A3 which are also overexpressed in EMC tumors. These genes and their products represent potential therapeutic targets for EMC tumors.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2012 PMID： 22592656 DOI： 10.1007/s13277-012-0415-2

Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283

44 in total

1. The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator.

Authors: Y Labelle; J Bussières; F Courjal; M B Goldring
Journal: Oncogene Date: 1999-05-27 Impact factor: 9.867

2. Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma.

Authors: H Sjögren; J Meis-Kindblom; L G Kindblom; P Aman; G Stenman
Journal: Cancer Res Date: 1999-10-15 Impact factor: 12.701

3. Identification of the human PHLDA1/TDAG51 gene: down-regulation in metastatic melanoma contributes to apoptosis resistance and growth deregulation.

Authors: Rüdiger Neef; Martina A Kuske; Elma Pröls; Judith P Johnson
Journal: Cancer Res Date: 2002-10-15 Impact factor: 12.701

4. Proteomics identification of ITGB3 as a key regulator in reactive oxygen species-induced migration and invasion of colorectal cancer cells.

Authors: Yunlong Lei; Kai Huang; Cong Gao; Quek Choon Lau; Hua Pan; Ke Xie; Jingyi Li; Rui Liu; Tao Zhang; Na Xie; Huey Shan Nai; Hong Wu; Qiang Dong; Xia Zhao; Edouard C Nice; Canhua Huang; Yuquan Wei
Journal: Mol Cell Proteomics Date: 2011-05-27 Impact factor: 5.911

5. alpha-Synuclein is expressed in a variety of brain tumors showing neuronal differentiation.

Authors: M Kawashima; S O Suzuki; K Doh-ura; T Iwaki
Journal: Acta Neuropathol Date: 2000-02 Impact factor: 17.088

6. Identification of a novel fusion gene involving hTAFII68 and CHN from a t(9;17)(q22;q11.2) translocation in an extraskeletal myxoid chondrosarcoma.

Authors: C Attwooll; M Tariq; M Harris; J D Coyne; N Telford; J M Varley
Journal: Oncogene Date: 1999-12-09 Impact factor: 9.867

7. Extraskeletal myxoid chondrosarcomas do not show a chondrocytic phenotype.

Authors: Thomas Aigner; André M Oliveira; Antonio G Nascimento
Journal: Mod Pathol Date: 2004-02 Impact factor: 7.842

8. The Wnt signaling inhibitor dickkopf-1 is required for reentry into the cell cycle of human adult stem cells from bone marrow.

Authors: Carl A Gregory; Harpreet Singh; Anthony S Perry; Darwin J Prockop
Journal: J Biol Chem Date: 2003-05-09 Impact factor: 5.157

9. Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma.

Authors: Christina M Annunziata; R Eric Davis; Yulia Demchenko; William Bellamy; Ana Gabrea; Fenghuang Zhan; Georg Lenz; Ichiro Hanamura; George Wright; Wenming Xiao; Sandeep Dave; Elaine M Hurt; Bruce Tan; Hong Zhao; Owen Stephens; Madhumita Santra; David R Williams; Lenny Dang; Bart Barlogie; John D Shaughnessy; W Michael Kuehl; Louis M Staudt
Journal: Cancer Cell Date: 2007-08 Impact factor: 31.743

Identification of genes regulated by the EWS/NR4A3 fusion protein in extraskeletal myxoid chondrosarcoma.

1. The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator.

2. Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma.

3. Identification of the human PHLDA1/TDAG51 gene: down-regulation in metastatic melanoma contributes to apoptosis resistance and growth deregulation.

4. Proteomics identification of ITGB3 as a key regulator in reactive oxygen species-induced migration and invasion of colorectal cancer cells.

5. alpha-Synuclein is expressed in a variety of brain tumors showing neuronal differentiation.

6. Identification of a novel fusion gene involving hTAFII68 and CHN from a t(9;17)(q22;q11.2) translocation in an extraskeletal myxoid chondrosarcoma.

7. Extraskeletal myxoid chondrosarcomas do not show a chondrocytic phenotype.

8. The Wnt signaling inhibitor dickkopf-1 is required for reentry into the cell cycle of human adult stem cells from bone marrow.

9. Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma.

10. RelB-dependent stromal cells promote T-cell leukemogenesis.

Review 1. The orphan nuclear receptors at their 25-year reunion.

2. EWSR1 regulates mitosis by dynamically influencing microtubule acetylation.

3. INSM1 expression and its diagnostic significance in extraskeletal myxoid chondrosarcoma.

Review 4. The interplay of NR4A receptors and the oncogene-tumor suppressor networks in cancer.