Literature DB >> 22591508

Identification of caerulomycin A gene cluster implicates a tailoring amidohydrolase.

Yiguang Zhu1, Peng Fu, Qinheng Lin, Guangtao Zhang, Haibo Zhang, Sumei Li, Jianhua Ju, Weiming Zhu, Changsheng Zhang.   

Abstract

The biosynthetic gene cluster for caerulomycin A (1) was cloned and characterized from the marine actinomycete Actinoalloteichus cyanogriseus WH1-2216-6, which revealed an unusual hybrid polyketide synthase (PKS)/nonribosomal peptide synthetase (NRPS) system. The crmL disruption mutant accumulated caerulomycin L (2) with an extended L-leucine at C-7, implicating an amidohydrolase activity for CrmL. The leucine-removing activity was confirmed for crude CrmL enzymes. Heterologous expression of the 1 gene cluster led to 1 production in Streptomyces coelicolor.

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Year:  2012        PMID： 22591508     DOI： 10.1021/ol300589r

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  13 in total

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2.  Non-ribosomal propeptide precursor in nocardicin A biosynthesis predicted from adenylation domain specificity dependent on the MbtH family protein NocI.

Authors:  Jeanne M Davidsen; David M Bartley; Craig A Townsend
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4.  Actinoalloteichus fjordicus sp. nov. isolated from marine sponges: phenotypic, chemotaxonomic and genomic characterisation.

Authors:  Imen Nouioui; Christian Rückert; Joost Willemse; Gilles P van Wezel; Hans-Peter Klenk; Tobias Busche; Jörn Kalinowski; Harald Bredholt; Sergey B Zotchev
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Review 5.  Cloning and Heterologous Expression of a Large-sized Natural Product Biosynthetic Gene Cluster in Streptomyces Species.

Authors:  Hee-Ju Nah; Hye-Rim Pyeon; Seung-Hoon Kang; Si-Sun Choi; Eung-Soo Kim
Journal:  Front Microbiol       Date:  2017-03-15       Impact factor: 5.640

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Authors:  Ming Chen; Bo Pang; Ya-Nan Du; Yi-Peng Zhang; Wen Liu
Journal:  Synth Syst Biotechnol       Date:  2017-07-13

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Journal:  Microb Cell Fact       Date:  2017-10-25       Impact factor: 5.328

10.  Activation and enhancement of caerulomycin A biosynthesis in marine-derived Actinoalloteichus sp. AHMU CJ021 by combinatorial genome mining strategies.

Authors:  Yunchang Xie; Jiawen Chen; Bo Wang; Tai Chen; Junyu Chen; Yuan Zhang; Xiaoying Liu; Qi Chen
Journal:  Microb Cell Fact       Date:  2020-08-06       Impact factor: 5.328
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