Alessandro Rubini1, Marco Redaelli, Andrea Parmagnani. 1. Department of Human Anatomy and Physiology, Section Physiology, University of Padova, Via Marzolo, Padova, Italy. alessandro.rubini@unipd.it
Abstract
CONTEXT: Angiotensin stimulates smooth-muscle contraction. Accordingly, angiotensin-converting enzyme (ACE) inhibition is expected to decrease airway resistance. OBJECTIVES: To measure the effects of ACE inhibition on respiratory mechanics in healthy mammals. MATERIALS AND METHODS: We measured respiratory mechanics before and after i.p. ACE inhibitor captopril (100 mg/kg) in normal anaesthetised rats. The end-inflation occlusion method allowed the measurements of respiratory system elastance and ohmic and viscoelastic pressure dissipations. Respiratory system hysteresis and the elastic and resistive work of breathing were calculated. RESULTS: Captopril induced a reduction of the ohmic and the total respiratory system resistances, while respiratory system hysteresis and elastance did not change. Accordingly, a reduction of the resistive and of the total work of breathing was observed. CONCLUSIONS: The captopril-induced reduction of airway resistance indicates that angiotensin modulates bronchomotor tone in basal conditions. ACE inhibition may positively affect respiratory system mechanics and work of breathing.
CONTEXT: Angiotensin stimulates smooth-muscle contraction. Accordingly, angiotensin-converting enzyme (ACE) inhibition is expected to decrease airway resistance. OBJECTIVES: To measure the effects of ACE inhibition on respiratory mechanics in healthy mammals. MATERIALS AND METHODS: We measured respiratory mechanics before and after i.p. ACE inhibitor captopril (100 mg/kg) in normal anaesthetised rats. The end-inflation occlusion method allowed the measurements of respiratory system elastance and ohmic and viscoelastic pressure dissipations. Respiratory system hysteresis and the elastic and resistive work of breathing were calculated. RESULTS:Captopril induced a reduction of the ohmic and the total respiratory system resistances, while respiratory system hysteresis and elastance did not change. Accordingly, a reduction of the resistive and of the total work of breathing was observed. CONCLUSIONS: The captopril-induced reduction of airway resistance indicates that angiotensin modulates bronchomotor tone in basal conditions. ACE inhibition may positively affect respiratory system mechanics and work of breathing.