Thomas W Buford1, Marco Pahor. 1. Department of Aging and Geriatric Research, College of Medicine, University of Florida, Gainesville, FL 32611, USA. tbuford@ufl.edu
Abstract
OBJECTIVE: This commentary offers a discussion of the need to consider behavioral interventions such as physical exercise as integral components of personalized medicine. METHODS: We discuss the concept of personalized medicine and review existing evidence of variability in response to exercise training. RESULTS: We argue that increased understanding is needed regarding sources of variability in exercise responsiveness, and that such understanding should lead to more tailored, often multimodal interventions. CONCLUSION: Studies of personalized medicine to date have primarily investigated heterogeneity in drug responsiveness; we believe it is time to begin considering preventive strategies such as exercise within a broader scope of personalized care.
OBJECTIVE: This commentary offers a discussion of the need to consider behavioral interventions such as physical exercise as integral components of personalized medicine. METHODS: We discuss the concept of personalized medicine and review existing evidence of variability in response to exercise training. RESULTS: We argue that increased understanding is needed regarding sources of variability in exercise responsiveness, and that such understanding should lead to more tailored, often multimodal interventions. CONCLUSION: Studies of personalized medicine to date have primarily investigated heterogeneity in drug responsiveness; we believe it is time to begin considering preventive strategies such as exercise within a broader scope of personalized care.
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