BACKGROUND: The diagnostic entity malignant fibrous histiocytoma (MFH) of bone is, like its soft tissue counterpart, likely to be a misnomer, encompassing a variety of poorly differentiated sarcomas. When reviewing a series of 57 so-called MFH of bone within the framework of the EuroBoNeT consortium according to up-to-date criteria and ancillary immunohistochemistry, a fourth of all tumors were reclassified and subtyped. METHODS: In the present study, the cytogenetic data on 11 of these tumors (three myoepithelioma-like sarcomas, two leiomyosarcomas, one undifferentiated pleomorphic sarcoma with incomplete myogenic differentiation, two undifferentiated pleomorphic sarcomas, one osteosarcoma, one spindle cell sarcoma, and one unclassifiable biphasic sarcoma) are presented. RESULTS: All tumors were high-grade lesions and showed very complex karyotypes. Neither the overall pattern (ploidy level, degree of complexity) nor specific cytogenetic features distinguished any of the subtypes. The subgroup of myoepithelioma-like sarcomas was further investigated with regard to the status of the EWSR1 and FUS loci; however, no rearrangement was found. Nor was any particular aberration that could differentiate any of the subtypes from osteosarcomas detected. CONCLUSIONS: chromosome banding analysis is unlikely to reveal potential genotype-phenotype correlations between morphologic subtypes among so-called MFH of bone.
BACKGROUND: The diagnostic entity malignant fibrous histiocytoma (MFH) of bone is, like its soft tissue counterpart, likely to be a misnomer, encompassing a variety of poorly differentiated sarcomas. When reviewing a series of 57 so-called MFH of bone within the framework of the EuroBoNeT consortium according to up-to-date criteria and ancillary immunohistochemistry, a fourth of all tumors were reclassified and subtyped. METHODS: In the present study, the cytogenetic data on 11 of these tumors (three myoepithelioma-like sarcomas, two leiomyosarcomas, one undifferentiated pleomorphic sarcoma with incomplete myogenic differentiation, two undifferentiated pleomorphic sarcomas, one osteosarcoma, one spindle cell sarcoma, and one unclassifiable biphasic sarcoma) are presented. RESULTS: All tumors were high-grade lesions and showed very complex karyotypes. Neither the overall pattern (ploidy level, degree of complexity) nor specific cytogenetic features distinguished any of the subtypes. The subgroup of myoepithelioma-like sarcomas was further investigated with regard to the status of the EWSR1 and FUS loci; however, no rearrangement was found. Nor was any particular aberration that could differentiate any of the subtypes from osteosarcomas detected. CONCLUSIONS: chromosome banding analysis is unlikely to reveal potential genotype-phenotype correlations between morphologic subtypes among so-called MFH of bone.
Authors: Maija Tarkkanen; Marcelo L Larramendy; Tom Böhling; Massimo Serra; Claudia M Hattinger; Aarne Kivioja; Inkeri Elomaa; Piero Picci; Sakari Knuutila Journal: Eur J Cancer Date: 2006-04-19 Impact factor: 9.162
Authors: Károly Szuhai; Marije Ijszenga; Danielle de Jong; Apollon Karseladze; Hans J Tanke; Pancras C W Hogendoorn Journal: Clin Cancer Res Date: 2009-03-24 Impact factor: 12.531
Authors: H Taubert; D Berger; R Hinze; A Meye; P Würl; P C Hogendoorn; H J Holzhausen; H Schmidt; F W Rath Journal: Cancer Lett Date: 1998-01-30 Impact factor: 8.679
Authors: Cristina R Antonescu; Lei Zhang; Ning-En Chang; Bruce R Pawel; William Travis; Nora Katabi; Morris Edelman; Andrew E Rosenberg; G Petur Nielsen; Paola Dal Cin; Christopher D M Fletcher Journal: Genes Chromosomes Cancer Date: 2010-12 Impact factor: 5.006
Authors: Salvatore Romeo; Judith V M G Bovée; Herman M Kroon; Roberto Tirabosco; Cristina Natali; Lucia Zanatta; Raf Sciot; Fredrik Mertens; Nick Athanasou; Marco Alberghini; Karoly Szuhai; Pancras C W Hogendoorn; Angelo Paolo Dei Tos Journal: Virchows Arch Date: 2012-09-22 Impact factor: 4.064