Literature DB >> 22588010

A randomized controlled trial of the efficacy and cost-effectiveness of a brief intensified cognitive behavioral therapy and/or pharmacotherapy for mood and anxiety disorders: design and methods.

Denise Meuldijk1, Ingrid V E Carlier, Irene M van Vliet, M Elske van den Akker-Marle, Frans G Zitman.   

Abstract

BACKGROUND: Anxiety and mood disorders involve a high disease burden and are associated with high economic costs. A stepped-care approach intervention and abbreviated diagnostic method are assumed to increase effectiveness and efficiency of the mental healthcare and are expected to reduce economic costs.
METHODS: Presented are the rationale, design, and methods of a two-armed randomized controlled trial comparing 'treatment as usual' (TAU) with a brief intensified cognitive behavioral therapy (CBT) and/or pharmacotherapy. Eligible participants (N=500) of five Dutch outpatient Mental Healthcare Centers are randomly assigned to either TAU or to the experimental condition (brief CBT and/or pharmacotherapy). Data on patients' progress and clinical effectiveness of treatment are assessed at baseline, post-treatment (3 months after baseline), and at 6 and 12 months post-treatment by Routine Outcome Monitoring (ROM). Cost analysis is performed on the obtained data. DISCUSSION: Since few studies have investigated both the clinical and cost effectiveness of a stepped-care approach intervention and a shortened diagnostic ROM method in both anxiety and/or mood disorders within secondary mental health care, the results of this study might contribute to the improvement of (cost)-effective treatment options and diagnostic methods for these disorders.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID: 22588010     DOI: 10.1016/j.cct.2012.05.002

Source DB:  PubMed          Journal:  Contemp Clin Trials        ISSN: 1551-7144            Impact factor:   2.226


  3 in total

1.  The index 'Treatment Duration Control' for enabling randomized controlled trials with variation in duration of treatment of chronic pain patients.

Authors:  Hilbert W van der Glas; Robert J van Grootel
Journal:  BMC Med Res Methodol       Date:  2013-10-11       Impact factor: 4.615

Review 2.  Handling Missing Data in Within-Trial Cost-Effectiveness Analysis: A Review with Future Recommendations.

Authors:  Andrea Gabrio; Alexina J Mason; Gianluca Baio
Journal:  Pharmacoecon Open       Date:  2017-06

3.  A Validation Study of the Web Screening Questionnaire (WSQ) Compared With the Mini-International Neuropsychiatric Interview-Plus (MINI-Plus).

Authors:  Denise Meuldijk; Erik J Giltay; Ingrid Ve Carlier; Irene M van Vliet; Albert M van Hemert; Frans G Zitman
Journal:  JMIR Ment Health       Date:  2017-08-29
  3 in total

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