Literature DB >> 2258706

Immunoregulatory role of transforming growth factor beta (TGF-beta) in development of killer cells: comparison of active and latent TGF-beta 1.

S C Wallick1, I S Figari, R E Morris, A D Levinson, M A Palladino.   

Abstract

Using recombinant DNA technology, we have generated Chinese hamster ovary (CHO) cell lines that synthesize latent transforming growth factor beta 1 (TGF-beta 1) to study immune regulation by TGF-beta 1. In vitro, latent TGF-beta 1 synthesized by transfectants or added exogenously as a purified complex after activation inhibited CTL generation to a similar extent as seen with acid-activated recombinant human (rHu) TGF-beta 1. In vivo, serum from nu/nu mice bearing CHO/TGF-beta 1 tumors contained significant levels of latent TGF-beta 1 in addition to depressed natural killer (NK) activity in spleens which paralleled that seen in C3H/HeJ mice treated with acid-activated rHuTGF-beta 1. rHuTGF-beta 1 treatment of mice receiving heart allografts resulted in significant enhancement of organ graft survival. Because of possible regulated tissue-specific activation, administration of latent rather than active TGF-beta may provide a better route to deliver this powerful immunosuppressive agent in vivo.

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Year:  1990        PMID： 2258706      PMCID： PMC2188774          DOI： 10.1084/jem.172.6.1777

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  47 in total

1.  Latent transforming growth factor-beta in serum. A specific complex with alpha 2-macroglobulin.

Authors:  M D O'Connor-McCourt; L M Wakefield
Journal:  J Biol Chem       Date:  1987-10-15       Impact factor: 5.157

2.  Transforming growth factor type beta induces monocyte chemotaxis and growth factor production.

Authors:  S M Wahl; D A Hunt; L M Wakefield; N McCartney-Francis; L M Wahl; A B Roberts; M B Sporn
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

3.  Expression and secretion of type beta transforming growth factor by activated human macrophages.

Authors:  R K Assoian; B E Fleurdelys; H C Stevenson; P J Miller; D K Madtes; E W Raines; R Ross; M B Sporn
Journal:  Proc Natl Acad Sci U S A       Date:  1987-09       Impact factor: 11.205

4.  Lysosomal and cytosolic sialidases in rabbit alveolar macrophages: demonstration of increased lysosomal activity after in vivo activation with bacillus Calmette-Guerin.

Authors:  Y Pilatte; J Bignon; C R Lambré
Journal:  Biochim Biophys Acta       Date:  1987-01-20

5.  Transforming growth factor-beta 1 (TGF-beta 1) and recombinant human tumor necrosis factor-alpha reciprocally regulate the generation of lymphokine-activated killer cell activity. Comparison between natural porcine platelet-derived TGF-beta 1 and TGF-beta 2, and recombinant human TGF-beta 1.

Authors:  T Espevik; I S Figari; G E Ranges; M A Palladino
Journal:  J Immunol       Date:  1988-04-01       Impact factor: 5.422

6.  Beta-transforming growth factor is stored in human blood platelets as a latent high molecular weight complex.

Authors:  R Pircher; P Jullien; D A Lawrence
Journal:  Biochem Biophys Res Commun       Date:  1986-04-14       Impact factor: 3.575

7.  Inhibition of cytokine production by cyclosporin A and transforming growth factor beta.

Authors:  T Espevik; I S Figari; M R Shalaby; G A Lackides; G D Lewis; H M Shepard; M A Palladino
Journal:  J Exp Med       Date:  1987-08-01       Impact factor: 14.307

8.  T cell suppressor factor from human glioblastoma cells is a 12.5-kd protein closely related to transforming growth factor-beta.

Authors:  M Wrann; S Bodmer; R de Martin; C Siepl; R Hofer-Warbinek; K Frei; E Hofer; A Fontana
Journal:  EMBO J       Date:  1987-06       Impact factor: 11.598

9.  Distribution and modulation of the cellular receptor for transforming growth factor-beta.

Authors:  L M Wakefield; D M Smith; T Masui; C C Harris; M B Sporn
Journal:  J Cell Biol       Date:  1987-08       Impact factor: 10.539

10.  Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha.

Authors:  G E Ranges; I S Figari; T Espevik; M A Palladino
Journal:  J Exp Med       Date:  1987-10-01       Impact factor: 14.307
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  24 in total

Review 1.  The extracellular regulation of growth factor action.

Authors:  R Flaumenhaft; D B Rifkin
Journal:  Mol Biol Cell       Date:  1992-10       Impact factor: 4.138

2.  Suppression of natural killer cell-mediated bone marrow cell rejection by CD4+CD25+ regulatory T cells.

Authors:  Isabel Barao; Alan M Hanash; William Hallett; Lisbeth A Welniak; Kai Sun; Doug Redelman; Bruce R Blazar; Robert B Levy; William J Murphy
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-27       Impact factor: 11.205

3.  Effect of FK 506 on FK-binding protein and transforming growth factor beta gene expression.

Authors:  P Rao; H Sun; J Snyder; J J Fung; T E Starzl
Journal:  Transplant Proc       Date:  1991-12       Impact factor: 1.066

Review 4.  Bone specific immunity and its impact on metastasis.

Authors:  Nikola Baschuk; Jay Rautela; Belinda S Parker
Journal:  Bonekey Rep       Date:  2015-04-15

5.  Serum transforming growth factor β1 during diabetes development in non-obese diabetic mice and humans.

Authors:  A Olivieri; S De Angelis; S Dionisi; G D'Annunzio; M Locatelli; M Marinaro; V Bonato; A Amendola; M Songini; F Velluzzi; C Schirru; R Cotichini; M A Stazi; F Dotta; R Lorini; G F Bottazzo; M Boirivant
Journal:  Clin Exp Immunol       Date:  2010-09-01       Impact factor: 4.330

6.  Transforming growth factor-beta 1 enhances the generation of allospecific cytotoxic T lymphocytes.

Authors:  S Kondo; K Isobe; N Ishiguro; I Nakashima; T Miura
Journal:  Immunology       Date:  1993-07       Impact factor: 7.397

7.  Transforming growth factor-beta (TGF-beta) isoforms in rat liver regeneration: messenger RNA expression and activation of latent TGF-beta.

Authors:  S B Jakowlew; J E Mead; D Danielpour; J Wu; A B Roberts; N Fausto
Journal:  Cell Regul       Date:  1991-07

8.  Transforming growth factor-beta-mediated down-regulation of antitumor cytotoxicity of spleen cells from MOPC-315 tumor-bearing mice engaged in tumor eradication following low-dose melphalan therapy.

Authors:  L M Weiskirch; Y Bar-Dagan; M B Mokyr
Journal:  Cancer Immunol Immunother       Date:  1994-04       Impact factor: 6.968

9.  Combination anti-CD2 and anti-CD3 monoclonal antibodies induce tolerance while altering interleukin-2, interleukin-4, tumor necrosis factor, and transforming growth factor-beta production.

Authors:  K D Chavin; L Qin; J Lin; J E Woodward; P Baliga; J S Bromberg
Journal:  Ann Surg       Date:  1993-10       Impact factor: 12.969

10.  A critical role for transforming growth factor-beta in donor transfusion-induced allograft tolerance.

Authors:  R Josien; P Douillard; C Guillot; M Müschen; I Anegon; J Chetritt; S Menoret; C Vignes; J P Soulillou; M C Cuturi
Journal:  J Clin Invest       Date:  1998-12-01       Impact factor: 14.808
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