| Literature DB >> 22586699 |
Peter Schwarz1, Anne Qvist Rasmussen, Torben M Kvist, Ulrik B Andersen, Niklas R Jørgensen.
Abstract
Bone affection in Paget's disease is characterized by increased bone turnover localised at one or more sites of the skeleton. Bisphosphonates are the drugs of choice when treating the increased bone turnover in Paget's disease. However, in cases of decreased kidney function only less effective treatments that are available as bisphosphonates are contraindicated in these patients. We present a case of a male patient aged 86 years with GFR of 11 mL/min and Paget's disease successfully treated by Denosumab. The bone turnover and pain decreased upon treatment.Entities:
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Year: 2012 PMID： 22586699 DOI： 10.1016/j.bone.2012.01.020
Source DB: PubMed Journal: Bone ISSN： 1873-2763 Impact factor: 4.398