| Literature DB >> 22586608 |
Nicola Aceto1, Mohamed Bentires-Alj.
Abstract
Lee-Hoeflich and colleagues use RNA interference screening to identify the serine/threonine phosphatase PPM1H as an inhibitor of trastuzumab resistance in vitro. This finding extends the molecular portrait of trastuzumab-resistant cells and provides a rationale when searching for potential therapeutic targets among regulators of PPM1H and/or its substrates. ©2011 AACR.Entities:
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Year: 2011 PMID： 22586608 DOI： 10.1158/2159-8290.CD-11-0185
Source DB: PubMed Journal: Cancer Discov ISSN： 2159-8274 Impact factor: 39.397