Literature DB >> 22586351

Kras, Pten, NF-κB, and inflammation: dangerous liaisons.

Paul J Chiao1, Jianhua Ling.   

Abstract

Ying and colleagues identify a novel function of Pten as a haploinsufficient tumor suppressor in human pancreatic cancer development. Genomic, genetic, and biochemical data reveal that Pten loss and Kras mutation cooperate to accelerate pancreatic cancer development by altering PI3K regulation to enhance NF-κB activation and upregulate downstream cytokine genes; this provides a protumorigenic and metastatic microenvironment.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 22586351     DOI： 10.1158/2159-8290.CD-11-0115

Source DB:  PubMed          Journal:  Cancer Discov        ISSN： 2159-8274            Impact factor:   39.397


  7 in total

1.  Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers.

Authors:  Nilanjana Chatterjee; Evangelos Pazarentzos; Manasi K Mayekar; Philippe Gui; David V Allegakoen; Gorjan Hrustanovic; Victor Olivas; Luping Lin; Erik Verschueren; Jeffrey R Johnson; Matan Hofree; Jenny J Yan; Billy W Newton; John V Dollen; Charles H Earnshaw; Jennifer Flanagan; Elton Chan; Saurabh Asthana; Trey Ideker; Wei Wu; Junji Suzuki; Benjamin A Barad; Yuriy Kirichok; James S Fraser; William A Weiss; Nevan J Krogan; Asmin Tulpule; Amit J Sabnis; Trever G Bivona
Journal:  Cell Rep       Date:  2019-08-27       Impact factor: 9.423

Review 2.  Cellular and molecular aspects of pancreatic cancer.

Authors:  A Gharibi; Y Adamian; J A Kelber
Journal:  Acta Histochem       Date:  2016-02-08       Impact factor: 2.479

3.  Time-Resolved and Comprehensive Analysis of Surface Glycoproteins Reveals Distinct Responses of Monocytes and Macrophages to Bacterial Infection.

Authors:  Suttipong Suttapitugsakul; Ming Tong; Ronghu Wu
Journal:  Angew Chem Weinheim Bergstr Ger       Date:  2021-03-08

4.  Time-Resolved and Comprehensive Analysis of Surface Glycoproteins Reveals Distinct Responses of Monocytes and Macrophages to Bacterial Infection.

Authors:  Suttipong Suttapitugsakul; Ming Tong; Ronghu Wu
Journal:  Angew Chem Int Ed Engl       Date:  2021-04-06       Impact factor: 15.336

5.  The overexpression of long intergenic ncRNA00162 induced by RelA/p65 promotes growth of pancreatic ductal adenocarcinoma.

Authors:  Yu Lu; Min Wu; Jie Fu; Yichen Sun; Kenei Furukawa; Jianhua Ling; Xue Qin; Paul J Chiao
Journal:  Cell Prolif       Date:  2020-05-04       Impact factor: 6.831

6.  The 'N-factors' in pancreatic cancer: functional relevance of NF-κB, NFAT and Nrf2 in pancreatic cancer.

Authors:  A Arlt; H Schäfer; H Kalthoff
Journal:  Oncogenesis       Date:  2012-11-26       Impact factor: 7.485

Review 7.  Biomarkers and Targeted Therapy in Pancreatic Cancer.

Authors:  Fataneh Karandish; Sanku Mallik
Journal:  Biomark Cancer       Date:  2016-04-26
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.