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Literature DB >> 22585855

New roles opined for OPCML.

Abstract

OPCML, frequently inactivated in ovarian tumors, mediates its antitumor effect via binding to the extracellular domains of several important oncogenic receptor tyrosine kinases (RTK). This, in turn, leads to the downregulation of RTKs in tumor cells and results in significant inhibition of tumor growth. ©2012 AACR.

Entities: Chemical Disease Gene Species

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Year: 2012 PMID： 22585855 PMCID： PMC3854967 DOI： 10.1158/2159-8290.CD-11-0356

Source DB: PubMed Journal: Cancer Discov ISSN： 2159-8274 Impact factor: 39.397

8 in total

Review 1. Solid lipid nanoparticles as a drug delivery system for peptides and proteins.

Authors: António J Almeida; Eliana Souto
Journal: Adv Drug Deliv Rev Date: 2007-05-01 Impact factor: 15.470

2. Expression of OBCAM-related cDNA clones in Cos 1 cells: evidence for a phosphatidylinositol linkage to the cell membrane.

Authors: M J Wick; G Fan; H H Loh
Journal: Brain Res Mol Brain Res Date: 1996-03

3. Expression of cellular adhesion molecule 'OPCML' is down-regulated in gliomas and other brain tumours.

Authors: J E Reed; J R Dunn; D G du Plessis; E J Shaw; P Reeves; A L Gee; P C Warnke; G C Sellar; D J Moss; C Walker
Journal: Neuropathol Appl Neurobiol Date: 2007-02 Impact factor: 8.090

4. Expression of ovarian tumour suppressor OPCML in the female CD-1 mouse reproductive tract.

Authors: Jean S Fleming; H James McQuillan; Melanie J Millier; Grant C Sellar
Journal: Reproduction Date: 2009-01-27 Impact factor: 3.906

5. OPCML gene promoter methylation and gene expression in tumor and stroma cells of invasive cervical carcinoma.

Authors: Feng Ye; Song-Fa Zhang; Xing Xie; Wei-Guo Lu
Journal: Cancer Invest Date: 2008-07 Impact factor: 2.176

6. OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer.

Authors: Grant C Sellar; Karen P Watt; Genevieve J Rabiasz; Euan A Stronach; Li Li; Eric P Miller; Charles E Massie; Jayne Miller; Bruno Contreras-Moreira; Diane Scott; Iain Brown; Alastair R Williams; Paul A Bates; John F Smyth; Hani Gabra
Journal: Nat Genet Date: 2003-07 Impact factor: 38.330

7. The OPCML tumor suppressor functions as a cell surface repressor-adaptor, negatively regulating receptor tyrosine kinases in epithelial ovarian cancer.

Authors: Arthur B McKie; Sebastian Vaughan; Elisa Zanini; Imoh S Okon; Louay Louis; Camila de Sousa; Mark I Greene; Qiang Wang; Roshan Agarwal; Dmitry Shaposhnikov; Joshua L C Wong; Hatice Gungor; Szymon Janczar; Mona El-Bahrawy; Eric W-F Lam; Naomi E Chayen; Hani Gabra
Journal: Cancer Discov Date: 2012-02 Impact factor: 39.397

8. OPCML is a broad tumor suppressor for multiple carcinomas and lymphomas with frequently epigenetic inactivation.

Authors: Yan Cui; Ying Ying; Andrew van Hasselt; Ka Man Ng; Jun Yu; Qian Zhang; Jie Jin; Dingxie Liu; Johng S Rhim; Sun Young Rha; Myriam Loyo; Anthony T C Chan; Gopesh Srivastava; George S W Tsao; Grant C Sellar; Joseph J Y Sung; David Sidransky; Qian Tao
Journal: PLoS One Date: 2008-08-20 Impact factor: 3.240

8 in total

4 in total

New roles opined for OPCML.

Review 1. Solid lipid nanoparticles as a drug delivery system for peptides and proteins.

2. Expression of OBCAM-related cDNA clones in Cos 1 cells: evidence for a phosphatidylinositol linkage to the cell membrane.

3. Expression of cellular adhesion molecule 'OPCML' is down-regulated in gliomas and other brain tumours.

4. Expression of ovarian tumour suppressor OPCML in the female CD-1 mouse reproductive tract.

5. OPCML gene promoter methylation and gene expression in tumor and stroma cells of invasive cervical carcinoma.

6. OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer.

7. The OPCML tumor suppressor functions as a cell surface repressor-adaptor, negatively regulating receptor tyrosine kinases in epithelial ovarian cancer.

8. OPCML is a broad tumor suppressor for multiple carcinomas and lymphomas with frequently epigenetic inactivation.

1. Loss of opioid binding protein/cell adhesion molecule-like gene expression in gastric cancer.

2. Novel DNA methylation targets in oral rinse samples predict survival of patients with oral squamous cell carcinoma.

Review 3. Emerging roles for the GPI-anchored tumor suppressor OPCML in cancers.

4. Environmental Correlation Analysis for Genes Associated with Protection against Malaria.