BACKGROUND AND OBJECTIVES: Protein tyrosine kinase 7 (PTK7) plays important functions in several cancer types but its expression in gastric cancer remains unknown. This study was designed to investigate PTK7 expression in gastric cancer. METHODS: PTK7 expression was assessed by immunohistochemistry in 201 gastric cancer patients. The relationship between PTK7 expression and clinicopathological features and patients prognosis were statistically analyzed. RESULTS: PTK7 expression was detected in 56.72% (114 of 201) of gastric cancer patients. The immunostaining was predominantly localized in the cytoplasm. The statistical analyses showed that PTK7 expression was more frequently detected in patients with well-differentiated tumors (P = 0.001). Furthermore, PTK7 expression was significantly related to the favorable overall survival (OS; P = 0.012) and disease-free survival (DFS; P = 0.009). Multivariate Cox regression analyses revealed that PTK7 expression was an independent prognostic factor for both favorable OS (P = 0.028) and DFS (P = 0.012). CONCLUSION: Our findings demonstrate that PTK7 can serve as a novel prognostic biomarker for gastric cancer patients.
BACKGROUND AND OBJECTIVES:Protein tyrosine kinase 7 (PTK7) plays important functions in several cancer types but its expression in gastric cancer remains unknown. This study was designed to investigate PTK7 expression in gastric cancer. METHODS:PTK7 expression was assessed by immunohistochemistry in 201 gastric cancerpatients. The relationship between PTK7 expression and clinicopathological features and patients prognosis were statistically analyzed. RESULTS:PTK7 expression was detected in 56.72% (114 of 201) of gastric cancerpatients. The immunostaining was predominantly localized in the cytoplasm. The statistical analyses showed that PTK7 expression was more frequently detected in patients with well-differentiated tumors (P = 0.001). Furthermore, PTK7 expression was significantly related to the favorable overall survival (OS; P = 0.012) and disease-free survival (DFS; P = 0.009). Multivariate Cox regression analyses revealed that PTK7 expression was an independent prognostic factor for both favorable OS (P = 0.028) and DFS (P = 0.012). CONCLUSION: Our findings demonstrate that PTK7 can serve as a novel prognostic biomarker for gastric cancerpatients.
Authors: Orit Jacobson; Ido D Weiss; Lu Wang; Zhe Wang; Xiangyu Yang; Andrew Dewhurst; Ying Ma; Guizhi Zhu; Gang Niu; Dale O Kiesewetter; Neil Vasdev; Steven H Liang; Xiaoyuan Chen Journal: J Nucl Med Date: 2015-08-27 Impact factor: 10.057
Authors: Silvia Gärtner; Angela Gunesch; Tatiana Knyazeva; Petra Wolf; Bernhard Högel; Wolfgang Eiermann; Axel Ullrich; Pjotr Knyazev; Beyhan Ataseven Journal: PLoS One Date: 2014-01-07 Impact factor: 3.240