CONTEXT: Spindle cell oncocytoma of the adenohypophysis (SCO) is a non-endocrine neoplasm with few recurrent forms described. It arises from the folliculo-stellate cells of the adenohypophysis. OBJECTIVE: We describe a case of SCO in a 24-year-old woman and provide pathogenetic information. DESIGN: Hematoxylin-eosin (H&E), and immunohistochemistry, with controls, for S100, SMI-311, neurofilament, EMA, CD68, GFAP, chromogranin, synaptophysin, and Ki67 were performed. CD44, nestin, Gli2, p-Akt(Ser 473) and p-mTOR(Ser 2448) antibodies were applied, and each analyte's cellular distribution and intensity were noted. RESULTS: H&E showed a proliferation of spindle and polygonal cells with a fascicular pattern, without mitoses. There was reactivity for SMI-311, CD44, nestin, S100, EMA, and vimentin. Neurofilament, CD68, chromogranin, synaptophysin, and GFAP were not expressed. p-Akt and p-mTOR were expressed suggesting mTORC2. Gli2 showed nuclear expression in the tumoral cells. CONCLUSIONS: These findings suggest that SCO has neuron-like precursor cells. Sonic hedgehog and mTOR pathways are activated.
CONTEXT: Spindle cell oncocytoma of the adenohypophysis (SCO) is a non-endocrine neoplasm with few recurrent forms described. It arises from the folliculo-stellate cells of the adenohypophysis. OBJECTIVE: We describe a case of SCO in a 24-year-old woman and provide pathogenetic information. DESIGN:Hematoxylin-eosin (H&E), and immunohistochemistry, with controls, for S100, SMI-311, neurofilament, EMA, CD68, GFAP, chromogranin, synaptophysin, and Ki67 were performed. CD44, nestin, Gli2, p-Akt(Ser 473) and p-mTOR(Ser 2448) antibodies were applied, and each analyte's cellular distribution and intensity were noted. RESULTS: H&E showed a proliferation of spindle and polygonal cells with a fascicular pattern, without mitoses. There was reactivity for SMI-311, CD44, nestin, S100, EMA, and vimentin. Neurofilament, CD68, chromogranin, synaptophysin, and GFAP were not expressed. p-Akt and p-mTOR were expressed suggesting mTORC2. Gli2 showed nuclear expression in the tumoral cells. CONCLUSIONS: These findings suggest that SCO has neuron-like precursor cells. Sonic hedgehog and mTOR pathways are activated.
Authors: Alexandra M Giantini Larsen; David J Cote; Hasan A Zaidi; Wenya Linda Bi; Paul J Schmitt; J Bryan Iorgulescu; Michael B Miller; Timothy R Smith; M Beatriz Lopes; John A Jane; Edward R Laws Journal: J Neurosurg Date: 2018-10-19 Impact factor: 5.115
Authors: Taha M Taka; Chen Yi Yang; Joshua N Limbo; Alvin Y Chan; Jordan Davies; Edward C Kuan; Scott G Turner; Frank P K Hsu Journal: J Neurosurg Case Lessons Date: 2021-10-04
Authors: Michael B Miller; Wenya Linda Bi; Lori A Ramkissoon; Yun Jee Kang; Malak Abedalthagafi; David S Knoff; Pankaj K Agarwalla; Patrick Y Wen; David A Reardon; Brian M Alexander; Edward R Laws; Ian F Dunn; Rameen Beroukhim; Keith L Ligon; Shakti H Ramkissoon Journal: Oncotarget Date: 2016-06-14