Literature DB >> 22585295

Enantioselective Friedel-Crafts alkylation of indoles with 2-enoylpyridine-N-oxides catalyzed by glucoBOX-Cu(II) complex.

Jimil George1, B V Subba Reddy.   

Abstract

The glucosamine derived glucoBOX-Cu(II) complex was found to be a unique catalytic system for enantioselective Friedel-Crafts alkylation of indoles with 2-enoylpyridine-1-oxides. A large number of 3-alkylated indole derivatives were prepared using 5 mol% glucoBOX-Cu(II) complex in excellent yields with high enantioselectivity up to 99% ee.

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Year:  2012        PMID： 22585295     DOI： 10.1039/c2ob25315a

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  3 in total

1.  Further Developments and Applications of Oxazoline-Containing Ligands in Asymmetric Catalysis.

Authors:  Robert Connon; Brendan Roche; Balaji V Rokade; Patrick J Guiry
Journal:  Chem Rev       Date:  2021-05-21       Impact factor: 60.622

2.  Orthogonal protection of saccharide polyols through solvent-free one-pot sequences based on regioselective silylations.

Authors:  Serena Traboni; Emiliano Bedini; Alfonso Iadonisi
Journal:  Beilstein J Org Chem       Date:  2016-12-14       Impact factor: 2.883

3.  Lewis Acid-Catalyzed Enantioselective Friedel-Crafts Alkylation of Pyrrole in Water.

Authors:  Jianan Sun; Yang Gui; Yekai Huang; Jindong Li; Zhenggen Zha; Yu Yang; Zhiyong Wang
Journal:  ACS Omega       Date:  2020-05-11
  3 in total

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