Literature DB >> 22585222

In vitro activities of LTX-109, a synthetic antimicrobial peptide, against methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, daptomycin-nonsusceptible, and linezolid-nonsusceptible Staphylococcus aureus.

Louis D Saravolatz1, Joan Pawlak, Leonard Johnson, Hector Bonilla, Louis D Saravolatz1, Mohamad G Fakih, Anders Fugelli, Wenche Marie Olsen.   

Abstract

LTX-109 and eight other antimicrobial agents were evaluated against 155 methicillin-resistant Staphylococcus aureus (MRSA) isolates, including strains resistant to vancomycin and strains with decreased susceptibility to daptomycin and linezolid, by microdilution tests to determine MICs. Time-kill assays were performed against representative MRSA, vancomycin-intermediate S. aureus (VISA), and vancomycin-resistant S. aureus (VRSA) isolates. LTX-109 demonstrated a MIC range of 2 to 4 μg/ml and dose-dependent rapid bactericidal activity against S. aureus. This activity was not influenced by resistance to other antistaphylococcal agents.

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Year:  2012        PMID： 22585222      PMCID： PMC3421571          DOI： 10.1128/AAC.00194-12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Synthetic antimicrobial peptidomimetics with therapeutic potential.

Authors:  Bengt Erik Haug; Wenche Stensen; Manar Kalaaji; Øystein Rekdal; John S Svendsen
Journal:  J Med Chem       Date:  2008-06-21       Impact factor: 7.446

2.  A synthetic antimicrobial peptidomimetic (LTX 109): stereochemical impact on membrane disruption.

Authors:  Johan Isaksson; Bjørn O Brandsdal; Magnus Engqvist; Gøril Eide Flaten; John S Mjøen Svendsen; Wenche Stensen
Journal:  J Med Chem       Date:  2011-07-26       Impact factor: 7.446

3.  Multicenter study to determine disk diffusion and broth microdilution criteria for prediction of high- and low-level mupirocin resistance in Staphylococcus aureus.

Authors:  Jana M Swenson; Betty Wong; Andrew E Simor; Richard B Thomson; Mary Jane Ferraro; Dwight J Hardy; Janet Hindler; James Jorgensen; L Barth Reller; Maria Traczewski; Linda K McDougal; Jean B Patel
Journal:  J Clin Microbiol       Date:  2010-05-05       Impact factor: 5.948

4.  In vitro activity of ceftaroline against community-associated methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, and daptomycin-nonsusceptible Staphylococcus aureus isolates.

Authors:  Louis Saravolatz; Joan Pawlak; Leonard Johnson
Journal:  Antimicrob Agents Chemother       Date:  2010-04-19       Impact factor: 5.191

5.  Outpatient antibiotic use in Europe and association with resistance: a cross-national database study.

Authors:  Herman Goossens; Matus Ferech; Robert Vander Stichele; Monique Elseviers
Journal:  Lancet       Date:  2005 Feb 12-18       Impact factor: 79.321

6.  Method of reliable determination of minimal lethal antibiotic concentrations.

Authors:  R D Pearson; R T Steigbigel; H T Davis; S W Chapman
Journal:  Antimicrob Agents Chemother       Date:  1980-11       Impact factor: 5.191

7.  Antimicrobial activities of twenty lysine-peptoid hybrids against clinically relevant bacteria and fungi.

Authors:  Trine S Ryge; Niels Frimodt-Møller; Paul R Hansen
Journal:  Chemotherapy       Date:  2008-03-07       Impact factor: 2.544

8.  Mupirocin resistance among methicillin-resistant Staphylococcus aureus-colonized patients at admission to a tertiary care medical center.

Authors:  Tara Babu; Violeta Rekasius; Jorge P Parada; Paul Schreckenberger; Malliswari Challapalli
Journal:  J Clin Microbiol       Date:  2009-05-27       Impact factor: 5.948

9.  Trends in antibacterial use in US academic health centers: 2002 to 2006.

Authors:  Amy L Pakyz; Conan MacDougall; Michael Oinonen; Ronald E Polk
Journal:  Arch Intern Med       Date:  2008-11-10
  9 in total
  20 in total

Review 1.  Antibiotics in the clinical pipeline at the end of 2015.

Authors:  Mark S Butler; Mark At Blaskovich; Matthew A Cooper
Journal:  J Antibiot (Tokyo)       Date:  2016-06-29       Impact factor: 2.649

Review 2.  Rediscovery of antimicrobial peptides as therapeutic agents.

Authors:  Minkyung Ryu; Jaeyeong Park; Ji-Hyun Yeom; Minju Joo; Kangseok Lee
Journal:  J Microbiol       Date:  2021-02-01       Impact factor: 3.422

3.  TXA709, an FtsZ-Targeting Benzamide Prodrug with Improved Pharmacokinetics and Enhanced In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus.

Authors:  Malvika Kaul; Lilly Mark; Yongzheng Zhang; Ajit K Parhi; Yi Lisa Lyu; Joan Pawlak; Stephanie Saravolatz; Louis D Saravolatz; Melvin P Weinstein; Edmond J LaVoie; Daniel S Pilch
Journal:  Antimicrob Agents Chemother       Date:  2015-06-01       Impact factor: 5.191

Review 4.  Advances in Development of Antimicrobial Peptidomimetics as Potential Drugs.

Authors:  Natalia Molchanova; Paul R Hansen; Henrik Franzyk
Journal:  Molecules       Date:  2017-08-29       Impact factor: 4.411

5.  Computational antimicrobial peptide design and evaluation against multidrug-resistant clinical isolates of bacteria.

Authors:  Deepesh Nagarajan; Tushar Nagarajan; Natasha Roy; Omkar Kulkarni; Sathyabaarathi Ravichandran; Madhulika Mishra; Dipshikha Chakravortty; Nagasuma Chandra
Journal:  J Biol Chem       Date:  2017-12-19       Impact factor: 5.157

6.  VanA and VanB Positive Vancomycin-resistant Staphylococcus aureus Among Clinical Isolates in Shiraz, South of Iran.

Authors:  Sareh Saadat; Kavous Solhjoo; Mohammad-Javad Norooz-Nejad; Akbar Kazemi
Journal:  Oman Med J       Date:  2014-09

7.  LTX-109 is a novel agent for nasal decolonization of methicillin-resistant and -sensitive Staphylococcus aureus.

Authors:  Anna C Nilsson; Håkan Janson; Hedda Wold; Anders Fugelli; Karin Andersson; Camilla Håkangård; Pernilla Olsson; Wenche Marie Olsen
Journal:  Antimicrob Agents Chemother       Date:  2014-10-20       Impact factor: 5.191

8.  Activity of tick antimicrobial peptide from Ixodes persulcatus (persulcatusin) against cell membranes of drug-resistant Staphylococcus aureus.

Authors:  Naruhide Miyoshi; Emiko Isogai; Keiichi Hiramatsu; Takashi Sasaki
Journal:  J Antibiot (Tokyo)       Date:  2016-08-17       Impact factor: 2.649

9.  Asp residues of βDELSEED-motif are required for peptide binding in the Escherichia coli ATP synthase.

Authors:  Zulfiqar Ahmad; Junior Tayou; Thomas F Laughlin
Journal:  Int J Biol Macromol       Date:  2015-01-17       Impact factor: 6.953

Review 10.  Antimicrobial peptides and peptidomimetics - potent therapeutic allies for staphylococcal infections.

Authors:  Haroon Mohammad; Shankar Thangamani; Mohamed N Seleem
Journal:  Curr Pharm Des       Date:  2015       Impact factor: 3.116
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