Literature DB >> 22585214

In vitro activity of TP-271 against Mycobacterium abscessus, Mycobacterium fortuitum, and Nocardia species.

Michael Cynamon1, Jeff Jureller, Balaji Desai, Krithika Ramachandran, Mary Sklaney, Trudy H Grossman.   

Abstract

The in vitro activities of TP-271, a novel fluorocycline antimicrobial, against 22 isolates of Mycobacterium abscessus, 22 isolates of Mycobacterium fortuitum, and 19 isolates of Nocardia spp. were studied by a microtiter broth dilution method. The MIC(90)s for M. abscessus, M. fortuitum, and Nocardia spp. were 0.5 μg/ml, 0.03 μg/ml, and 8 μg/ml, respectively. TP-271 was significantly more active than the respective control drug in virtually all tests.

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Year:  2012        PMID： 22585214      PMCID： PMC3393423          DOI： 10.1128/AAC.00743-12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  8 in total

1.  Fluorocyclines. 1. 7-fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline: a potent, broad spectrum antibacterial agent.

Authors:  Xiao-Yi Xiao; Diana K Hunt; Jingye Zhou; Roger B Clark; Nick Dunwoody; Corey Fyfe; Trudy H Grossman; William J O'Brien; Louis Plamondon; Magnus Rönn; Cuixiang Sun; Wu-Yan Zhang; Joyce A Sutcliffe
Journal:  J Med Chem       Date:  2012-01-04       Impact factor: 7.446

2.  Fluorocyclines. 2. Optimization of the C-9 side-chain for antibacterial activity and oral efficacy.

Authors:  Roger B Clark; Diana K Hunt; Minsheng He; Catherine Achorn; Chi-Li Chen; Yonghong Deng; Corey Fyfe; Trudy H Grossman; Philip C Hogan; William J O'Brien; Louis Plamondon; Magnus Rönn; Joyce A Sutcliffe; Zhijian Zhu; Xiao-Yi Xiao
Journal:  J Med Chem       Date:  2012-01-06       Impact factor: 7.446

3.  Infections due to rapidly growing mycobacteria.

Authors:  Mary A De Groote; Gwen Huitt
Journal:  Clin Infect Dis       Date:  2006-05-11       Impact factor: 9.079

Review 4.  Mycobacterium abscessus: a new antibiotic nightmare.

Authors:  Rachid Nessar; Emmanuelle Cambau; Jean Marc Reyrat; Alan Murray; Brigitte Gicquel
Journal:  J Antimicrob Chemother       Date:  2012-01-30       Impact factor: 5.790

5.  Comparison of the in vitro activity of the glycylcycline tigecycline (formerly GAR-936) with those of tetracycline, minocycline, and doxycycline against isolates of nontuberculous mycobacteria.

Authors:  Richard J Wallace; Barbara A Brown-Elliott; Christopher J Crist; Linda Mann; Rebecca W Wilson
Journal:  Antimicrob Agents Chemother       Date:  2002-10       Impact factor: 5.191

Review 6.  Actinomycoses and Nocardia pulmonary infections.

Authors:  Orhan Yildiz; Mehmet Doganay
Journal:  Curr Opin Pulm Med       Date:  2006-05       Impact factor: 3.155

Review 7.  Pulmonary nocardiosis: risk factors, clinical features, diagnosis and prognosis.

Authors:  Raquel Martínez; Soledad Reyes; Rosario Menéndez
Journal:  Curr Opin Pulm Med       Date:  2008-05       Impact factor: 3.155

8.  In vitro activities of tigecycline and 10 other antimicrobials against nonpigmented rapidly growing mycobacteria.

Authors:  R Fernández-Roblas; N Z Martín-de-Hijas; A I Fernández-Martínez; D García-Almeida; I Gadea; J Esteban
Journal:  Antimicrob Agents Chemother       Date:  2008-08-25       Impact factor: 5.191
  8 in total
  4 in total

Review 1.  NTM drug discovery: status, gaps and the way forward.

Authors:  Mu-Lu Wu; Dinah B Aziz; Véronique Dartois; Thomas Dick
Journal:  Drug Discov Today       Date:  2018-04-07       Impact factor: 7.851

Review 2.  Pipeline of anti-Mycobacterium abscessus small molecules: Repurposable drugs and promising novel chemical entities.

Authors:  Anna Egorova; Mary Jackson; Victor Gavrilyuk; Vadim Makarov
Journal:  Med Res Rev       Date:  2021-03-01       Impact factor: 12.388

Review 3.  Pipeline of Known Chemical Classes of Antibiotics.

Authors:  Cristina d'Urso de Souza Mendes; Adelaide Maria de Souza Antunes
Journal:  Antibiotics (Basel)       Date:  2013-12-06

Review 4.  Looking beyond Typical Treatments for Atypical Mycobacteria.

Authors:  Clara M Bento; Maria Salomé Gomes; Tânia Silva
Journal:  Antibiotics (Basel)       Date:  2020-01-03
  4 in total

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