Literature DB >> 22583912

Application of hypoiodite-mediated aminyl radical cyclization to synthesis of solasodine acetate.

Yi Kou1, Myong Chul Koag, Young Cheun, Aram Shin, Seongmin Lee.   

Abstract

Solasodine acetate, an anticancer steroidal alkaloid, was synthesized from diosgenin in 8 steps with an overall yield of 23%. A key synthetic step involves the formation of 5/6-oxazaspiroketal moiety via hypoiodite-mediated aminyl radical cyclization of a steroidal primary amine.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22583912     DOI： 10.1016/j.steroids.2012.05.002

Source DB:  PubMed          Journal:  Steroids        ISSN： 0039-128X            Impact factor:   2.668


  27 in total

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Authors:  Zhongjing Zhang; Wanqing Weng; Weiguo Huang; Boda Wu; Yi Zhou; Jie Zhang; Tuo Deng; Wen Ye; Jiecheng Zhang; Jianyang Ao; Qiyu Zhang; Keqing Shi
Journal:  Aging (Albany NY)       Date:  2020-06-30       Impact factor: 5.682

2.  Population pharmacokinetics and individualized lobaplatin regimen for the treatment of Chinese small cell lung cancer in the elderly.

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Authors:  Cheng Xiao; Jiong Qian; Yulong Zheng; Fang Song; Qiangfeng Wang; Haiping Jiang; Chenyu Mao; Nong Xu
Journal:  Medicine (Baltimore)       Date:  2019-05       Impact factor: 1.817

4.  Clinical efficacy of oral immunoglobulin Y in infant rotavirus enteritis: Systematic review and meta-analysis.

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Journal:  Medicine (Baltimore)       Date:  2019-07       Impact factor: 1.817

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Authors:  Fan Zhang; Yantong Yin; Tiantian Xu
Journal:  Medicine (Baltimore)       Date:  2019-08       Impact factor: 1.817

6.  Non-steroidal anti-inflammatory drugs and risk of mortality in lung cancer: A meta-analysis of 5 prospective cohorts studies.

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Journal:  Medicine (Baltimore)       Date:  2019-08       Impact factor: 1.817

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Authors:  Li Jiang; Yong Zhang; Zhendong Yang; Feifei Liang; Jiangtao Wu; Rensheng Wang
Journal:  Medicine (Baltimore)       Date:  2019-08       Impact factor: 1.889

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Authors:  Ping Li; Liuhua Wang; Pengfei Li; Fangyong Hu; Yi Cao; Dong Tang; Gang Ye; Hongbo Li; Daorong Wang
Journal:  Aging (Albany NY)       Date:  2020-11-05       Impact factor: 5.682

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Authors:  Junmin Chen; Jianyong Chen; Jingrong Lu
Journal:  Evid Based Complement Alternat Med       Date:  2020-07-14       Impact factor: 2.629

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Authors:  Xiaoyu Zhang; Weibin Chen; Jie Bai; Lijun Jin; Xiaoning Kang; Hui Zhang; Zunyi Wang
Journal:  Aging (Albany NY)       Date:  2020-05-12       Impact factor: 5.682
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