Literature DB >> 2258326

Epimerization of erythromycin derivatives.

J Firl1, A Prox, P Luger, R Maier, E Woitun, K Daneck.   

Abstract

Dirithromycin (3) isomerizes upon dissolution in different solvents. From X-ray analysis of V-T 108, an analogue of dirithromycin, and comparative 1H and 13C NMR, and MS data, the isomer of dirithromycin was confirmed to be the C-16-(S)-epimer. The ratio of the two epimers at equilibrium conditions was approximately 8:2 (R/S) in methanol at room temperature.

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Year:  1990        PMID： 2258326     DOI： 10.7164/antibiotics.43.1271

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  3 in total

1.  Synthesis and antimicrobial evaluation of dirithromycin (AS-E 136; LY237216), a new macrolide antibiotic derived from erythromycin.

Authors:  F T Counter; P W Ensminger; D A Preston; C Y Wu; J M Greene; A M Felty-Duckworth; J W Paschal; H A Kirst
Journal:  Antimicrob Agents Chemother       Date:  1991-06       Impact factor: 5.191

2.  A computational approach to the synthesis of dirithromycin.

Authors:  Dilek Duran; Viktorya Aviyente; Canan Baysal
Journal:  J Mol Model       Date:  2004-01-13       Impact factor: 1.810

3.  Antimicrobial characterization and interrelationships of dirithromycin and epidirithromycin.

Authors:  H A Kirst; L C Creemer; J W Paschal; D A Preston; W E Alborn; F T Counter; J G Amos; R L Clemens; K A Sullivan; J M Greene
Journal:  Antimicrob Agents Chemother       Date:  1995-07       Impact factor: 5.191
  3 in total

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