| Literature DB >> 22582931 |
Ajesh P Thomas1, P S Saneesh Babu, S Asha Nair, S Ramakrishnan, Danaboyina Ramaiah, Tavarekere K Chandrashekar, A Srinivasan, M Radhakrishna Pillai.
Abstract
A water-soluble derivative of N-confused porphyrin (NCP) was synthesized, and the photodynamic therapeutic (PDT) application was investigated by photophysical and in vitro studies. High singlet oxygen quantum yield in water at longer wavelength and promising IC(50) values in a panel of cancer cell lines ensure the potential candidacy of the sensitizer as a PDT drug. Reactive oxygen species (ROS) generation on PDT in MDA-MB 231 cells and the apoptotic pathway of cell death was illustrated using different techniques.Entities:
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Year: 2012 PMID： 22582931 DOI： 10.1021/jm300009q
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446