BACKGROUND: Skull base tumors are associated with physical symptoms that vary depending on location and surgical approach. METHODS: Skull base surgery patients (n = 138) were retrospectively reviewed and physical symptoms were quantified. Patients were divided into 4 groups by surgical approach (open, endoscopic) and tumor location (anterior, central). Multivariate analyses determined odds for symptom development. RESULTS: Patients with anterior lesions presented with more nasal symptoms compared to those with central lesions (63% vs 6.8%; p < .001). Those with central lesions presented with more neurologic (41.1% vs 12.3%; p < .001) and endocrine symptoms (19.2% vs 0%; p < .001). Three of 4 groups experienced a reduction in neurologic and visual symptoms after surgery. One group (endoscopic/central) experienced a reduction in endocrine and an increase in nasal symptoms. Anterior tumors (p = .02) and endoscopic approaches (p = .002) predicted increased nasal morbidity. CONCLUSION: Physical morbidity from skull base tumors may vary based on tumor location and surgical approach.
BACKGROUND: Skull base tumors are associated with physical symptoms that vary depending on location and surgical approach. METHODS: Skull base surgery patients (n = 138) were retrospectively reviewed and physical symptoms were quantified. Patients were divided into 4 groups by surgical approach (open, endoscopic) and tumor location (anterior, central). Multivariate analyses determined odds for symptom development. RESULTS:Patients with anterior lesions presented with more nasal symptoms compared to those with central lesions (63% vs 6.8%; p < .001). Those with central lesions presented with more neurologic (41.1% vs 12.3%; p < .001) and endocrine symptoms (19.2% vs 0%; p < .001). Three of 4 groups experienced a reduction in neurologic and visual symptoms after surgery. One group (endoscopic/central) experienced a reduction in endocrine and an increase in nasal symptoms. Anterior tumors (p = .02) and endoscopic approaches (p = .002) predicted increased nasal morbidity. CONCLUSION: Physical morbidity from skull base tumors may vary based on tumor location and surgical approach.
Authors: Wouter R van Furth; Amir H Zamanipoor Najafabadi; Merel van der Meulen; Marco J T Verstegen; Daniel J Lobatto; Maarten C Kleijwegt; Alberto M Pereira; Nienke R Biermasz Journal: Pituitary Date: 2022-01-10 Impact factor: 4.107
Authors: Soroush Larjani; Eric Monteiro; Ian Witterick; Allan Vescan; Gelareh Zadeh; Fred Gentili; David P Goldstein; John R de Almeida Journal: J Otolaryngol Head Neck Surg Date: 2016-09-07
Authors: Alfred Marc Calo Iloreta; Gurston G Nyquist; Mark Friedel; Christopher Farrell; Marc R Rosen; James J Evans Journal: J Neurol Surg Rep Date: 2014-11-12