INTRODUCTION: To assess age- and sex-specific myasthenia gravis (MG) occurrence and incidence in the different geographical regions in Norway and thereby to identify factors that may contribute to the development of MG. METHODS: Multiple Poisson regression analysis was used to assess variation in incidence dependent on year, gender and onset age in five geographically defined health regions. RESULTS: The study population comprised 419 individuals with first time seropositive tests from 1995 to 2007. Annual MG incidence ranged from < 1 to 14 per million, with an average of 7.04 per million for all five health regions combined. CONCLUSIONS: This is the first nation-wide epidemiological study of seropositive MG that elucidates the geographical differences within a country. The incidence of seropositive MG did not vary significantly between the regions. Mid-Norway tended to have a higher incidence, and North tended to have a lower incidence.
INTRODUCTION: To assess age- and sex-specific myasthenia gravis (MG) occurrence and incidence in the different geographical regions in Norway and thereby to identify factors that may contribute to the development of MG. METHODS: Multiple Poisson regression analysis was used to assess variation in incidence dependent on year, gender and onset age in five geographically defined health regions. RESULTS: The study population comprised 419 individuals with first time seropositive tests from 1995 to 2007. Annual MG incidence ranged from < 1 to 14 per million, with an average of 7.04 per million for all five health regions combined. CONCLUSIONS: This is the first nation-wide epidemiological study of seropositive MG that elucidates the geographical differences within a country. The incidence of seropositive MG did not vary significantly between the regions. Mid-Norway tended to have a higher incidence, and North tended to have a lower incidence.
Authors: Ralf J Ludwig; Karen Vanhoorelbeke; Frank Leypoldt; Ziya Kaya; Katja Bieber; Sandra M McLachlan; Lars Komorowski; Jie Luo; Otavio Cabral-Marques; Christoph M Hammers; Jon M Lindstrom; Peter Lamprecht; Andrea Fischer; Gabriela Riemekasten; Claudia Tersteeg; Peter Sondermann; Basil Rapoport; Klaus-Peter Wandinger; Christian Probst; Asmaa El Beidaq; Enno Schmidt; Alan Verkman; Rudolf A Manz; Falk Nimmerjahn Journal: Front Immunol Date: 2017-05-31 Impact factor: 7.561
Authors: Atakan Tanacan; Erdem Fadiloglu; Gonca Ozten; Ali Can Gunes; Gokcen Orgul; Mehmet Sinan Beksac Journal: Ir J Med Sci Date: 2019-05-09 Impact factor: 1.568