Edo Y Birati1, Michael Eldar, Bernard Belhassen. 1. Department of Cardiology, Tel Aviv Sourasky Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. ebirati@hotmail.com
Abstract
BACKGROUND: Recent studies have shown that the pathogenesis of accessory connections (AC) formation may have a genetic component. OBJECTIVE: The purpose of the study was to examine whether AC location differs by gender in a large cohort of patients with AC undergoing radiofrequency ablation (RFA) in two Israeli electrophysiology (EP) laboratories. METHODS: All consecutive patients who underwent RFA of single ACs in Tel Aviv Sourasky Medical Center between 1992 and 2009 (n = 574) as well as the first consecutive 230 patients who underwent RFA in Sheba Medical Center between 1992 and 2001 were included in this study. RESULTS: The 804 patients in the two centers included 511 males (63.6 %) and 293 (36.4 %) females, mean age 34 + 16 years old. The AC was located in the left free wall, posteroseptal, right free wall, right anteroseptal, and in other areas in 57.8, 22.8, 9.3, 7 and 3.1 % of patients, respectively. The anatomical AC distribution was similar in the two EP laboratories. A right free wall location was more frequent in females (13 %) than in males (7.2 %; p = 0.008). A right anteroseptal location was more frequent in males (8.4 %) than in females (4.4 %) (p = 0.043). The left free wall and posteroseptal locations were similarly encountered in males (58.1 and 23.1 %, respectively) and in females (57.3 and 22.2 %, respectively). CONCLUSIONS: In our Israeli population, females more commonly have right free wall ACs and males more commonly have right anteroseptal ACs. These findings support the possible role of a genetic component in the pathogenesis of AC formation.
BACKGROUND: Recent studies have shown that the pathogenesis of accessory connections (AC) formation may have a genetic component. OBJECTIVE: The purpose of the study was to examine whether AC location differs by gender in a large cohort of patients with AC undergoing radiofrequency ablation (RFA) in two Israeli electrophysiology (EP) laboratories. METHODS: All consecutive patients who underwent RFA of single ACs in Tel Aviv Sourasky Medical Center between 1992 and 2009 (n = 574) as well as the first consecutive 230 patients who underwent RFA in Sheba Medical Center between 1992 and 2001 were included in this study. RESULTS: The 804 patients in the two centers included 511 males (63.6 %) and 293 (36.4 %) females, mean age 34 + 16 years old. The AC was located in the left free wall, posteroseptal, right free wall, right anteroseptal, and in other areas in 57.8, 22.8, 9.3, 7 and 3.1 % of patients, respectively. The anatomical AC distribution was similar in the two EP laboratories. A right free wall location was more frequent in females (13 %) than in males (7.2 %; p = 0.008). A right anteroseptal location was more frequent in males (8.4 %) than in females (4.4 %) (p = 0.043). The left free wall and posteroseptal locations were similarly encountered in males (58.1 and 23.1 %, respectively) and in females (57.3 and 22.2 %, respectively). CONCLUSIONS: In our Israeli population, females more commonly have right free wall ACs and males more commonly have right anteroseptal ACs. These findings support the possible role of a genetic component in the pathogenesis of AC formation.
Authors: M H Gollob; M S Green; A S Tang; T Gollob; A Karibe; A S Ali Hassan ; F Ahmad; R Lozado; G Shah; L Fananapazir; L L Bachinski; R Roberts; A S Hassan Journal: N Engl J Med Date: 2001-06-14 Impact factor: 91.245
Authors: Michael Arad; Ivan P Moskowitz; Vickas V Patel; Ferhaan Ahmad; Antonio R Perez-Atayde; Douglas B Sawyer; Mark Walter; Guo H Li; Patrick G Burgon; Colin T Maguire; David Stapleton; Joachim P Schmitt; X X Guo; Anne Pizard; Sabina Kupershmidt; Dan M Roden; Charles I Berul; Christine E Seidman; J G Seidman Journal: Circulation Date: 2003-06-02 Impact factor: 29.690
Authors: Jonathan C Hsu; Ronn E Tanel; Byron K Lee; Melvin M Scheinman; Nitish Badhwar; Randall J Lee; Zian H Tseng; Jeffrey E Olgin; Gregory M Marcus Journal: Heart Rhythm Date: 2009-09-19 Impact factor: 6.343
Authors: Kathy N Wright; Chad E Connor; Holly M Irvin; Timothy K Knilans; Dawn Webber; Philip H Kass Journal: J Vet Intern Med Date: 2018-09-14 Impact factor: 3.333