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Literature DB >> 22580560

Efficiency and specificity in microRNA biogenesis.

Omer Barad¹, Mati Mann, Elik Chapnik, Archana Shenoy, Robert Blelloch, Naama Barkai, Eran Hornstein.

Abstract

Primary microRNA cleavage by the Drosha-Dgcr8 'Microprocessor' complex is critical for microRNA biogenesis. Yet, the Microprocessor may also cleave other nuclear RNAs in a nonspecific manner. We studied Microprocessor function using mathematical modeling and experiments in mouse and human tissues. We found that the autoregulatory feedback on Microprocessor expression is instrumental for balancing the efficiency and specificity of its activity by effectively tuning Microprocessor levels to those of its pri-miRNA substrate.

Entities: CellLine Chemical Gene Species

Mesh：

Substances：

Year: 2012 PMID： 22580560 PMCID： PMC4378260 DOI： 10.1038/nsmb.2293

Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369

19 in total

Review 1. MicroRNAs: genomics, biogenesis, mechanism, and function.

Authors: David P Bartel
Journal: Cell Date: 2004-01-23 Impact factor: 41.582

2. RecA-mediated homology search as a nearly optimal signal detection system.

Authors: Yonatan Savir; Tsvi Tlusty
Journal: Mol Cell Date: 2010-11-12 Impact factor: 17.970

3. The Microprocessor complex mediates the genesis of microRNAs.

Authors: Richard I Gregory; Kai-Ping Yan; Govindasamy Amuthan; Thimmaiah Chendrimada; Behzad Doratotaj; Neil Cooch; Ramin Shiekhattar
Journal: Nature Date: 2004-11-07 Impact factor: 49.962

4. Post-transcriptional control of DGCR8 expression by the Microprocessor.

Authors: Robinson Triboulet; Hao-Ming Chang; Robert J Lapierre; Richard I Gregory
Journal: RNA Date: 2009-04-21 Impact factor: 4.942

5. Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model.

Authors: Kimberly L Stark; Bin Xu; Anindya Bagchi; Wen-Sung Lai; Hui Liu; Ruby Hsu; Xiang Wan; Paul Pavlidis; Alea A Mills; Maria Karayiorgou; Joseph A Gogos
Journal: Nat Genet Date: 2008-05-11 Impact factor: 38.330

6. Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases.

Authors: Fedor V Karginov; Sihem Cheloufi; Mark M W Chong; Alexander Stark; Andrew D Smith; Gregory J Hannon
Journal: Mol Cell Date: 2010-06-25 Impact factor: 17.970

7. Canonical and alternate functions of the microRNA biogenesis machinery.

Authors: Mark M W Chong; Guoan Zhang; Sihem Cheloufi; Thomas A Neubert; Gregory J Hannon; Dan R Littman
Journal: Genes Dev Date: 2010-08-16 Impact factor: 11.361

8. Posttranscriptional crossregulation between Drosha and DGCR8.

Authors: Jinju Han; Jakob S Pedersen; S Chul Kwon; Cassandra D Belair; Young-Kook Kim; Kyu-Hyeon Yeom; Woo-Young Yang; David Haussler; Robert Blelloch; V Narry Kim
Journal: Cell Date: 2009-01-09 Impact factor: 41.582

9. Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex.

Authors: Claude M Schofield; Ruby Hsu; Alison J Barker; Caitlyn C Gertz; Robert Blelloch; Erik M Ullian
Journal: Neural Dev Date: 2011-04-05 Impact factor: 3.842

10. Genomic analysis suggests that mRNA destabilization by the microprocessor is specialized for the auto-regulation of Dgcr8.

Authors: Archana Shenoy; Robert Blelloch
Journal: PLoS One Date: 2009-09-11 Impact factor: 3.240

11 in total

1. Let-7 and miR-125 cooperate to prime progenitors for astrogliogenesis.

Authors: Archana Shenoy; Muhammad Danial; Robert H Blelloch
Journal: EMBO J Date: 2015-02-23 Impact factor: 11.598

Review 2. MicroRNAs and synaptic plasticity--a mutual relationship.

Authors: Ayla Aksoy-Aksel; Federico Zampa; Gerhard Schratt
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2014-09-26 Impact factor: 6.237

3. DGCR8 is essential for tumor progression following PTEN loss in the prostate.

Authors: Cassandra D Belair; Alireza Paikari; Felix Moltzahn; Archana Shenoy; Christina Yau; Marc Dall'Era; Jeff Simko; Christopher Benz; Robert Blelloch
Journal: EMBO Rep Date: 2015-07-23 Impact factor: 8.807

4. MicroRNA-Target Network Inference and Local Network Enrichment Analysis Identify Two microRNA Clusters with Distinct Functions in Head and Neck Squamous Cell Carcinoma.

Authors: Steffen Sass; Adriana Pitea; Kristian Unger; Julia Hess; Nikola S Mueller; Fabian J Theis
Journal: Int J Mol Sci Date: 2015-12-18 Impact factor: 5.923

5. DGCR8-mediated production of canonical microRNAs is critical for regulatory T cell function and stability.

Authors: Lukas T Jeker; Xuyu Zhou; Robert Blelloch; Jeffrey A Bluestone
Journal: PLoS One Date: 2013-05-31 Impact factor: 3.240

6. Drosha promotes splicing of a pre-microRNA-like alternative exon.

Authors: Mallory A Havens; Ashley A Reich; Michelle L Hastings
Journal: PLoS Genet Date: 2014-05-01 Impact factor: 5.917

7. Induction of exportin-5 expression during melanoma development supports the cellular behavior of human malignant melanoma cells.

Authors: Corinna Anna Ott; Lisa Linck; Elisabeth Kremmer; Gunter Meister; Anja Katrin Bosserhoff
Journal: Oncotarget Date: 2016-09-20