Literature DB >> 22580230

Leishmania chagasi naturally resistant to nitric oxide isolated from humans and dogs with visceral leishmaniasis in Brazil.

P L Santos1, R V Costa, J M Braz, L F V C Santos, A C Batista, C R O Vasconcelos, M R Rangel, A Ribeiro de Jesus, T R de Moura, P T G Leopoldo, R P Almeida.   

Abstract

Nitric oxide (NO) plays an important role as a leishmanicidal agent in murine macrophages. NO resistant Escherichia coli and Mycobacterium tuberculosis have been associated with poor outcomes of their resulting diseases. NO resistant Leishmania braziliensis has also been identified and exacerbates the clinical course of human leishmaniasis. We report, for the first time, natural resistance of Leishmania chagasi promastigotes to NO. These parasites were isolated from humans and dogs with visceral leishmaniasis. We also demonstrate that this resistance profile was associated with a greater survival capacity and a greater parasite burden in murine macrophages, independent of activation and after activation by IFN-γ and LPS.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22580230     DOI： 10.1016/j.niox.2012.04.004

Source DB:  PubMed          Journal:  Nitric Oxide        ISSN： 1089-8603            Impact factor:   4.427


  11 in total

1.  Cross-resistance of Leishmania infantum isolates to nitric oxide from patients refractory to antimony treatment, and greater tolerance to antileishmanial responses by macrophages.

Authors:  Tatiana R de Moura; Micheli Luize Barbosa Santos; Juciene M Braz; Luis Felipe V C Santos; Matheus T Aragão; Fabricia A de Oliveira; Priscila L Santos; Ângela Maria da Silva; Amélia Ribeiro de Jesus; Roque P de Almeida
Journal:  Parasitol Res       Date:  2016-02       Impact factor: 2.289

2.  Fatty acid profiles in Leishmania spp. isolates with natural resistance to nitric oxide and trivalent antimony.

Authors:  Alana Freire de Azevedo; Jorge Luís de Lisboa Dutra; Micheli Luize Barbosa Santos; Darlisson de Alexandria Santos; Péricles Barreto Alves; Tatiana Rodrigues de Moura; Roque Pacheco de Almeida; Marcelo Ferreira Fernandes; Ricardo Scher; Roberta Pereira Miranda Fernandes
Journal:  Parasitol Res       Date:  2013-10-06       Impact factor: 2.289

3.  Antimony resistance associated with persistence of Leishmania (Leishmania) infantum infection in macrophages.

Authors:  Lucas Sousa Magalhães; Lays Gisele Santos Bomfim; Camilla Natália Oliveira Santos; Priscila Lima Dos Santos; Diego Moura Tanajura; Michael Wheeler Lipscomb; Amélia Ribeiro de Jesus; Roque Pacheco de Almeida; Tatiana Rodrigues de Moura
Journal:  Parasitol Res       Date:  2021-07-17       Impact factor: 2.289

4.  Increased thiol levels in antimony-resistant Leishmania infantum isolated from treatment-refractory visceral leishmaniasis in Brazil.

Authors:  Lucas S Magalhães; Lays Gs Bomfim; Sthefanne G Mota; Geydson S Cruz; Cristiane B Corrêa; Diego M Tanajura; Michael W Lipscomb; Valéria M Borges; Amélia R de Jesus; Roque P de Almeida; Tatiana R de Moura
Journal:  Mem Inst Oswaldo Cruz       Date:  2018-02       Impact factor: 2.743

5.  Moroccan strains of Leishmania major and Leishmania tropica differentially impact on nitric oxide production by macrophages.

Authors:  Hasnaa Maksouri; Pham My-Chan Dang; Vasco Rodrigues; Jérôme Estaquier; Myriam Riyad; Khadija Akarid
Journal:  Parasit Vectors       Date:  2017-10-23       Impact factor: 3.876

6.  Premature deaths by visceral leishmaniasis in Brazil investigated through a cohort study: A challenging opportunity?

Authors:  Ana Nilce S Maia-Elkhoury; Gustavo Adolfo Sierra Romero; Samantha Y O B Valadas; Marcia L Sousa-Gomes; José Angelo Lauletta Lindoso; Elisa Cupolillo; Jose Antonio Ruiz-Postigo; Daniel Argaw; Manuel J Sanchez-Vazquez
Journal:  PLoS Negl Trop Dis       Date:  2019-12-19

7.  Expression of inducible nitric oxide synthase in macrophages inversely correlates with parasitism of lymphoid tissues in dogs with visceral leishmaniasis.

Authors:  Françoise P Sanches; Thaise Y Tomokane; Vânia L R Da Matta; Mary Marcondes; Carlos E P Corbett; Márcia D Laurenti
Journal:  Acta Vet Scand       Date:  2014-09-07       Impact factor: 1.695

8.  In vitro activity of phospholipase A2 and of peptides from Crotalus durissus terrificus venom against amastigote and promastigote forms of Leishmania (L.) infantum chagasi.

Authors:  Gustavo A C Barros; Andreia V Pereira; Luciana C Barros; Airton Lourenço; Sueli A Calvi; Lucilene D Santos; Benedito Barraviera; Rui Seabra Ferreira
Journal:  J Venom Anim Toxins Incl Trop Dis       Date:  2015-11-24

9.  Infection of Human Macrophages by Leishmania infantum Is Influenced by Ecto-Nucleotidases.

Authors:  Nalu Teixeira de Aguiar Peres; Luana Celina Seraphim Cunha; Meirielly Lima Almeida Barbosa; Márcio Bezerra Santos; Fabrícia Alvise de Oliveira; Amélia Maria Ribeiro de Jesus; Roque Pacheco de Almeida
Journal:  Front Immunol       Date:  2018-01-11       Impact factor: 7.561

10.  Genomic and Metabolomic Polymorphism among Experimentally Selected Paromomycin-Resistant Leishmania donovani Strains.

Authors:  C D Shaw; H Imamura; T Downing; G Blackburn; G D Westrop; J A Cotton; M Berriman; M Sanders; S Rijal; G H Coombs; J C Dujardin; K C Carter
Journal:  Antimicrob Agents Chemother       Date:  2019-12-20       Impact factor: 5.191
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