Literature DB >> 22580061

Translational CNS medicines research.

Alan M Palmer1, Mohammad S Alavijeh.   

Abstract

The major imperative of the pharmaceutical industry is to effectively translate insights gained from basic research into new medicines. This task is toughest for CNS disorders. Compared with non-CNS drugs, CNS drugs take longer to get to market and their attrition rate is greater. This is principally because of the complexity of the human brain (the cause of many brain disorders remains unknown), the liability of CNS drugs to cause CNS side effects (which limits their use) and the requirement of CNS medicines to cross the blood-CNS barrier (BCNSB) (which restricts their ability to interact with their CNS target). In this review we consider the factors that are important in translating neuroscience research into CNS medicines.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22580061     DOI： 10.1016/j.drudis.2012.05.001

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  14 in total

Review 1.  Physiologically based pharmacokinetic modelling of drug penetration across the blood-brain barrier--towards a mechanistic IVIVE-based approach.

Authors:  Kathryn Ball; François Bouzom; Jean-Michel Scherrmann; Bernard Walther; Xavier Declèves
Journal:  AAPS J       Date:  2013-06-20       Impact factor: 4.009

Review 2.  Nanoparticles and the blood-brain barrier: advancing from in-vitro models towards therapeutic significance.

Authors:  David J Mc Carthy; Meenakshi Malhotra; Aoife M O'Mahony; John F Cryan; Caitriona M O'Driscoll
Journal:  Pharm Res       Date:  2014-12-02       Impact factor: 4.200

3.  Synthesis and in Vitro Studies of a Series of Carborane-Containing Boron Dipyrromethenes (BODIPYs).

Authors:  Sunting Xuan; Ning Zhao; Zehua Zhou; Frank R Fronczek; M Graça H Vicente
Journal:  J Med Chem       Date:  2016-02-17       Impact factor: 7.446

4.  Drugs acting on central nervous system (CNS) targets as leads for non-CNS targets.

Authors:  Prashant S Kharkar
Journal:  F1000Res       Date:  2014-02-06

5.  Optimization of touchscreen-based behavioral paradigms in mice: implications for building a battery of tasks taxing learning and memory functions.

Authors:  David Delotterie; Chantal Mathis; Jean-Christophe Cassel; Cornelia Dorner-Ciossek; Anelise Marti
Journal:  PLoS One       Date:  2014-06-24       Impact factor: 3.240

Review 6.  Drug delivery in overcoming the blood-brain barrier: role of nasal mucosal grafting.

Authors:  Carlotta Marianecci; Federica Rinaldi; Patrizia Nadia Hanieh; Luisa Di Marzio; Donatella Paolino; Maria Carafa
Journal:  Drug Des Devel Ther       Date:  2017-01-27       Impact factor: 4.162

7.  Multiple sclerosis and the blood-central nervous system barrier.

Authors:  Alan M Palmer
Journal:  Cardiovasc Psychiatry Neurol       Date:  2013-01-15

8.  Pharmacokinetics, biodistribution and metabolism of squalenoyl adenosine nanoparticles in mice using dual radio-labeling and radio-HPLC analysis.

Authors:  Alice Gaudin; Sinda Lepetre-Mouelhi; Julie Mougin; Martine Parrod; Grégory Pieters; Sébastien Garcia-Argote; Olivier Loreau; Jordan Goncalves; Hélène Chacun; Yann Courbebaisse; Pascal Clayette; Didier Desmaële; Bernard Rousseau; Karine Andrieux; Patrick Couvreur
Journal:  J Control Release       Date:  2015-06-16       Impact factor: 9.776

9.  Squalenoyl adenosine nanoparticles provide neuroprotection after stroke and spinal cord injury.

Authors:  Alice Gaudin; Müge Yemisci; Hakan Eroglu; Sinda Lepetre-Mouelhi; Omer Faruk Turkoglu; Buket Dönmez-Demir; Seçil Caban; Mustafa Fevzi Sargon; Sébastien Garcia-Argote; Grégory Pieters; Olivier Loreau; Bernard Rousseau; Oya Tagit; Niko Hildebrandt; Yannick Le Dantec; Julie Mougin; Sabrina Valetti; Hélène Chacun; Valérie Nicolas; Didier Desmaële; Karine Andrieux; Yilmaz Capan; Turgay Dalkara; Patrick Couvreur
Journal:  Nat Nanotechnol       Date:  2014-11-24       Impact factor: 39.213

10.  A novel human induced pluripotent stem cell blood-brain barrier model: Applicability to study antibody-triggered receptor-mediated transcytosis.

Authors:  Maria Ribecco-Lutkiewicz; Caroline Sodja; Julie Haukenfrers; Arsalan S Haqqani; Dao Ly; Peter Zachar; Ewa Baumann; Marguerite Ball; Jez Huang; Marina Rukhlova; Marzia Martina; Qing Liu; Danica Stanimirovic; Anna Jezierski; Mahmud Bani-Yaghoub
Journal:  Sci Rep       Date:  2018-01-30       Impact factor: 4.379
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