| Literature DB >> 22579839 |
Wisanu Maneerat1, Wong Phakhodee, Thunwadee Ritthiwigrom, Sarot Cheenpracha, Trinop Promgool, Kulsiri Yossathera, Suwanna Deachathai, Surat Laphookhieo.
Abstract
Three new carbazole alkaloids, harmandianamines A-C (1-3), together with fifteen known compounds (4-18) were isolated from the twigs of Clausena harmandiana. The structures were elucidated by spectroscopic methods, including UV, IR, NMR, and MS. The antibacterial activity against Escherichia coli TISTR 780, Salmonella typhimurium TISTR 292, Staphylococcus aureus TISTR 1466 and methicillin-resistant S. aureus (MRSA) SK1 of some isolated compounds was also evaluated. Compound 6 exhibited significant antibacterial activity against MRSA SK1 with an MIC value of 0.25 μg/mL which higher than that of standard drug, vancomycin (MIC value=1 μg/mL) whereas compounds 14 and 5 showed strong activity with MIC values of 4 and 8 μg/mL, respectively. Only compound 14 showed strong antibacterial activity against S. aureus TISTR 1466 with an MIC value of 4 μg/mL.Entities:
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Year: 2012 PMID： 22579839 DOI： 10.1016/j.fitote.2012.04.026
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882