Literature DB >> 225798

Calmodulin activation of adenylate cyclase in pancreatic islets.

I Valverde, A Vandermeers, R Anjaneyulu, W J Malaisse.   

Abstract

Pancreatic islets contain calmodulin. The protein binds to a particulate fraction derived from the islets and stimulates adenylate cyclase activity in this subcellular fraction, both phenomena being activated by ionized calcium. A calcium-dependent stimulation of adenylate cyclase by endogenous calmodulin may contribute to the accumulation of adenosine 3',5'-monophosphate evoked by insulin releasing agents in the islet cells.

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Year:  1979        PMID： 225798     DOI： 10.1126/science.225798

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  48 in total

1.  PRMT1 promotes glucose toxicity-induced β cell dysfunction by regulating the nucleo-cytoplasmic trafficking of PDX-1 in a FOXO1-dependent manner in INS-1 cells.

Authors:  Lixia Lv; Hewen Chen; Jiaying Sun; Di Lu; Chen Chen; Dongfang Liu
Journal:  Endocrine       Date:  2015-02-10       Impact factor: 3.633

2.  Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line.

Authors:  Luis R Landa; Mark Harbeck; Kelly Kaihara; Oleg Chepurny; Kajorn Kitiphongspattana; Oliver Graf; Viacheslav O Nikolaev; Martin J Lohse; George G Holz; Michael W Roe
Journal:  J Biol Chem       Date:  2005-06-29       Impact factor: 5.157

3.  Stimulation by glucose of cyclic AMP accumulation in mouse pancreatic islets is mediated by protein kinase C.

Authors:  P Thams; K Capito; C J Hedeskov
Journal:  Biochem J       Date:  1988-07-01       Impact factor: 3.857

4.  Role of the tumor suppressor IQGAP2 in metabolic homeostasis: Possible link between diabetes and cancer.

Authors:  B Vaitheesvaran; K Hartil; A Navare; P OBroin; A Golden; Wn Lee; I J Kurland; J E Bruce
Journal:  Metabolomics       Date:  2014-10-01       Impact factor: 4.290

5.  Calcium dependency and free calcium concentrations during insulin secretion in a hamster beta cell line.

Authors:  A E Boyd; R S Hill; J M Oberwetter; M Berg
Journal:  J Clin Invest       Date:  1986-03       Impact factor: 14.808

Review 6.  A la recherche du temps perdu--epilogue to the Minkowski Award lecture 1974.

Authors:  E Cerasi
Journal:  Diabetologia       Date:  1985-08       Impact factor: 10.122

7.  Roles of intracellular Ca2+ receptors in the pancreatic beta-cell in insulin secretion.

Authors:  I Niki; H Hidaka
Journal:  Mol Cell Biochem       Date:  1999-01       Impact factor: 3.396

8.  GTP is not required for calmodulin stimulation of bovine brain adenylate cyclase.

Authors:  W Heideman; B M Wierman; D R Storm
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

9.  Insulin secretion by a transplantable rat islet cell tumour.

Authors:  A M Sopwith; J C Hutton; S P Naber; W L Chick; C N Hales
Journal:  Diabetologia       Date:  1981-09       Impact factor: 10.122

Review 10.  Aspects of novel sites of regulation of the insulin stimulus-secretion coupling in normal and diabetic pancreatic islets.

Authors:  A Sjöholm
Journal:  Endocrine       Date:  1998-08       Impact factor: 3.633
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