Literature DB >> 22579758

Nanofiber-based delivery of bioactive agents and stem cells to bone sites.

Zhanpeng Zhang1, Jiang Hu, Peter X Ma.   

Abstract

Biodegradable nanofibers are important scaffolding materials for bone regeneration. In this paper, the basic concepts and recent advances of self-assembly, electrospinning and thermally induced phase separation techniques that are widely used to generate nanofibrous scaffolds are reviewed. In addition, surface functionalization and bioactive factor delivery within these nanofibrous scaffolds to enhance bone regeneration are also discussed. Moreover, recent progresses in applying these nanofiber-based scaffolds to deliver stem cells for bone regeneration are presented. Along with the significant advances, challenges and obstacles in the field as well as the future perspective are discussed.
Copyright © 2012 Elsevier B.V. All rights reserved.

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Year:  2012        PMID： 22579758      PMCID： PMC3419794          DOI： 10.1016/j.addr.2012.04.008

Source DB:  PubMed          Journal:  Adv Drug Deliv Rev        ISSN： 0169-409X            Impact factor:   15.470


  167 in total

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Authors:  Sun-Woong Kang; Hee Seok Yang; Sang-Woo Seo; Dong Keun Han; Byung-Soo Kim
Journal:  J Biomed Mater Res A       Date:  2008-06-01       Impact factor: 4.396

Review 3.  Electrospinning: applications in drug delivery and tissue engineering.

Authors:  Travis J Sill; Horst A von Recum
Journal:  Biomaterials       Date:  2008-02-20       Impact factor: 12.479

4.  Surface-functionalized electrospun nanofibers for tissue engineering and drug delivery.

Authors:  Hyuk Sang Yoo; Taek Gyoung Kim; Tae Gwan Park
Journal:  Adv Drug Deliv Rev       Date:  2009-07-27       Impact factor: 15.470

5.  A review on electrospinning design and nanofibre assemblies.

Authors:  W E Teo; S Ramakrishna
Journal:  Nanotechnology       Date:  2006-06-30       Impact factor: 3.874

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Journal:  J Biomed Mater Res       Date:  1998-02

7.  Robust, efficient, and orthogonal synthesis of dendrimers via thiol-ene "click" chemistry.

Authors:  Kato L Killops; Luis M Campos; Craig J Hawker
Journal:  J Am Chem Soc       Date:  2008-03-20       Impact factor: 15.419

8.  The fabrication of nano-hydroxyapatite on PLGA and PLGA/collagen nanofibrous composite scaffolds and their effects in osteoblastic behavior for bone tissue engineering.

Authors:  Michelle Ngiam; Susan Liao; Avinash J Patil; Ziyuan Cheng; Casey K Chan; S Ramakrishna
Journal:  Bone       Date:  2009-04-07       Impact factor: 4.398

Review 9.  Self-assembling materials for therapeutic delivery.

Authors:  Monica C Branco; Joel P Schneider
Journal:  Acta Biomater       Date:  2008-10-10       Impact factor: 8.947

10.  Mesenchymal stem cells.

Authors:  A I Caplan
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  32 in total

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Journal:  Tissue Eng       Date:  2007-09

2.  Simultaneous Nano- and Microscale Control of Nanofibrous Microspheres Self-Assembled from Star-Shaped Polymers.

Authors:  Zhanpeng Zhang; Ryan L Marson; Zhishen Ge; Sharon C Glotzer; Peter X Ma
Journal:  Adv Mater       Date:  2015-05-26       Impact factor: 30.849

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4.  Semi-interpenetrating network (sIPN) gelatin nanofiber scaffolds for oral mucosal drug delivery.

Authors:  Donald C Aduba; Jeremy A Hammer; Quan Yuan; W Andrew Yeudall; Gary L Bowlin; Hu Yang
Journal:  Acta Biomater       Date:  2013-02-13       Impact factor: 8.947

5.  Biomimetic electrospun nanofibrous structures for tissue engineering.

Authors:  Xianfeng Wang; Bin Ding; Bingyun Li
Journal:  Mater Today (Kidlington)       Date:  2013-06-01       Impact factor: 31.041

6.  Microspheres Assembled from Chitosan-Graft-Poly(lactic acid) Micelle-Like Core-Shell Nanospheres for Distinctly Controlled Release of Hydrophobic and Hydrophilic Biomolecules.

Authors:  Xufeng Niu; Zhongning Liu; Jiang Hu; Kunal J Rambhia; Yubo Fan; Peter X Ma
Journal:  Macromol Biosci       Date:  2016-03-14       Impact factor: 4.979

Review 7.  Advances in biologic augmentation for rotator cuff repair.

Authors:  Sahishnu Patel; Anthony P Gualtieri; Helen H Lu; William N Levine
Journal:  Ann N Y Acad Sci       Date:  2016-10-17       Impact factor: 5.691

8.  Characterization of a bioactive fiber scaffold with entrapped HUVECs in coaxial electrospun core-shell fiber.

Authors:  Hui Ying Ang; Scott Alexander Irvine; Ron Avrahami; Udi Sarig; Tomer Bronshtein; Eyal Zussman; Freddy Yin Chiang Boey; Marcelle Machluf; Subbu S Venkatraman
Journal:  Biomatter       Date:  2014-02-19

9.  In vitro and in vivo studies of BMP-2-loaded PCL-gelatin-BCP electrospun scaffolds.

Authors:  Bo-Ram Kim; Thuy Ba Linh Nguyen; Young-Ki Min; Byong-Taek Lee
Journal:  Tissue Eng Part A       Date:  2014-12       Impact factor: 3.845

Review 10.  Controlled drug release for tissue engineering.

Authors:  Kunal J Rambhia; Peter X Ma
Journal:  J Control Release       Date:  2015-08-29       Impact factor: 9.776
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