| Literature DB >> 22579486 |
Jeffrey M Axten1, Jesús R Medina, Charles W Blackledge, Céline Duquenne, Seth W Grant, Mark A Bobko, Tony Peng, William H Miller, Theresa Pinckney, Timothy F Gallagher, Swarupa Kulkarni, Thomas Lewandowski, Glenn S Van Aller, Rimma Zonis, Paris Ward, Nino Campobasso.
Abstract
A new class of PDF inhibitor with potent, broad spectrum antibacterial activity is described. Optimization of blood stability and potency provided compounds with improved pharmacokinetics that were suitable for in vivo experiments. Compound 5c, which has robust antibacterial activity, demonstrated efficacy in two respiratory tract infection models.Entities:
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Year: 2012 PMID： 22579486 DOI： 10.1016/j.bmcl.2012.04.086
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823