Literature DB >> 2257873

Influence of food on the bioavailability of metoprolol from an OROS system; a study in healthy volunteers.

G van den Berg1, F van Steveninck, J M Gubbens-Stibbe, H C Schoemaker, A G de Boer, A F Cohen.   

Abstract

The influence of food intake on the bioavailability of metoprolol from an OROS system has been investigated. No significant difference was found between OROS administration to fasting subjects or after breakfast in any of the kinetic parameters (AUC, Cmax, tmax, C24 and lag time). Therefore, metoprolol OROS can be administered with breakfast.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2257873     DOI： 10.1007/bf00315121

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  4 in total

1.  Influence of food intake on plasma oxprenolol concentrations following oral administration of conventional and Oros preparations.

Authors:  V A John; S E Smith
Journal:  Br J Clin Pharmacol       Date:  1985       Impact factor: 4.335

Review 2.  Clinical pharmacokinetics of metoprolol.

Authors:  C G Regårdh; G Johnsson
Journal:  Clin Pharmacokinet       Date:  1980 Nov-Dec       Impact factor: 6.447

3.  Investigation of drug absorption from the gastrointestinal tract of man. I. Metoprolol in the stomach, duodenum and jejunum.

Authors:  G Jobin; A Cortot; J Godbillon; M Duval; J P Schoeller; J Hirtz; J J Bernier
Journal:  Br J Clin Pharmacol       Date:  1985       Impact factor: 4.335

4.  Investigation of drug absorption from the gastrointestinal tract of man. II. Metoprolol in the jejunum and ileum.

Authors:  N Vidon; D Evard; J Godbillon; M Rongier; M Duval; J P Schoeller; J J Bernier; J Hirtz
Journal:  Br J Clin Pharmacol       Date:  1985       Impact factor: 4.335
  4 in total
  7 in total

Review 1.  A Review of Food-Drug Interactions on Oral Drug Absorption.

Authors:  Jianyuan Deng; Xiao Zhu; Zongmeng Chen; Chun Ho Fan; Him Shek Kwan; Chi Ho Wong; Ka Yi Shek; Zhong Zuo; Tai Ning Lam
Journal:  Drugs       Date:  2017-11       Impact factor: 9.546

Review 2.  Pharmacokinetic studies in healthy volunteers in the context of in vitro/in vivo correlations.

Authors:  B Oosterhuis; J H Jonkman
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1993 Jan-Mar       Impact factor: 2.441

Review 3.  Novel oral drug formulations. Their potential in modulating adverse effects.

Authors:  A T Florence; P U Jani
Journal:  Drug Saf       Date:  1994-03       Impact factor: 5.606

Review 4.  Effects of food on clinical pharmacokinetics.

Authors:  B N Singh
Journal:  Clin Pharmacokinet       Date:  1999-09       Impact factor: 6.447

Review 5.  Controlled release metoprolol formulations. A review of their pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and ischaemic heart disease.

Authors:  G L Plosker; S P Clissold
Journal:  Drugs       Date:  1992-03       Impact factor: 9.546

6.  Stable isotope methodology for studying the performance of metoprolol Oros tablets in comparison to conventional and slow release formulations.

Authors:  J Richard; J M Cardot; J Godbillon
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1994 Oct-Dec       Impact factor: 2.441

7.  Extended-Release Once-Daily Formulation of Tofacitinib: Evaluation of Pharmacokinetics Compared With Immediate-Release Tofacitinib and Impact of Food.

Authors:  Manisha Lamba; Rong Wang; Tracey Fletcher; Christine Alvey; Joseph Kushner; Thomas C Stock
Journal:  J Clin Pharmacol       Date:  2016-11       Impact factor: 3.126
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.