| Literature DB >> 22578509 |
M M Shulaeva1, S G Fattakhov, L F Saifina, R V Chestnova, R Sh Valijev, D N Mingaleev, A D Voloshina, V S Reznik.
Abstract
A series of novel 1,3-dimethylisocyanurates has been synthesized as potential inhibitors of β-ketoacyl synthase in mycobacteria. Most of the 25 compounds described and tested for their activity against M. tuberculosis have a bacteriostatic effect, comparable and even higher that of first-line antituberculosis drugs. These compounds are nontoxic, species-specific, exhibiting no activity against other bacterial species.Entities:
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Year: 2012 PMID： 22578509 DOI： 10.1016/j.ejmech.2012.04.014
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514