| Literature DB >> 22578461 |
Aesop Cho1, Lijun Zhang, Jie Xu, Darius Babusis, Thomas Butler, Rick Lee, Oliver L Saunders, Ting Wang, Jay Parrish, Jason Perry, Joy Y Feng, Adrian S Ray, Choung U Kim.
Abstract
A series of 2'-C-methyl branched purine and pyrimidine C-nucleosides were prepared. Their anti-HCV activity and pharmacological properties were profiled, and compared with known 2'-C-Me N-nucleoside counterparts. In particular, 2'-C-Me 4-aza-7,9-dideazaadenosine C-nucleoside (2) was found to have potent and selective anti-HCV activity in vitro as well as a favorable pharmacokinetic profile and in vivo potential for enhanced potency over the corresponding N-nucleoside.Entities:
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Year: 2012 PMID： 22578461 DOI： 10.1016/j.bmcl.2012.04.065
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823