| Literature DB >> 22578454 |
Li Xiao1, Yi Zhang, Zequan Yang, Yaqin Xu, Bijoy Kundu, Mahendra D Chordia, Dongfeng Pan.
Abstract
A PECAM-1 specific PET imaging agent, PECAM-1-Ab-DOTA-(64)Cu, was synthesized by conjugating the anti-mouse PECAM-1 antibody with 2,2',2",2"'-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid (DOTA) and subsequent labeling with (64)Cu. Positron Emission Tomography (PET) was successfully performed in a mouse model of myocardial infarction (MI) induced by an ischemia/reperfusion (I/R) injury, indicating the elevated expression of PECAM-1. Published by Elsevier Ltd.Entities:
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Year: 2012 PMID： 22578454 DOI： 10.1016/j.bmcl.2012.04.059
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823