Literature DB >> 22578453

Synthesis, characterization and in vitro anti-tumor activities of matrine derivatives.

Lisheng Wang1, Yejun You, Songqing Wang, Xu Liu, Buming Liu, Jinni Wang, Xiao Lin, Mingsheng Chen, Gang Liang, Hua Yang.   

Abstract

Nineteen previously unreported matrine derivatives were synthesized and characterized using elemental analysis, infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, and mass spectrometry. Target compounds 6a-6l and 7a-7c showed stronger inhibitory activities than matrine in the in vitro antitumor tests and inhibited the growth of the Hep7402, B16-F10, A549, and TW03 cell lines. In addition, compound 6i exhibited a potent antitumor activity similar to that of colchicine.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22578453     DOI： 10.1016/j.bmcl.2012.04.069

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

1.  Ochrocephalamine A, a new quinolizidine alkaloid from Oxytropis ochrocephala Bunge.

Authors:  Li-Na Liu; Jian-Qiang Ran; Li-Jun Li; Yu Zhao; Masuo Goto; Susan L Morris-Natschke; Kuo-Hsiung Lee; Bao-Yu Zhao; Cheng-Jian Tan
Journal:  Tetrahedron Lett       Date:  2016-10-04       Impact factor: 2.415

2.  Effect of matrine on primary human hepatocytes in vitro.

Authors:  Xiaobing Gong; Yuan Gao; Guoqing Guo; Florian W R Vondran; Ruth Schwartlander; Ekaterina Efimova; Gesine Pless; Igor M Sauera; Peter Neuhaus
Journal:  Cytotechnology       Date:  2014-01-21       Impact factor: 2.058

3.  Synthesis, biological evaluation and mechanism studies of matrine derivatives as anticancer agents.

Authors:  Lihe Jiang; Lichuan Wu; Fangfang Yang; Nadin Almosnid; Xu Liu; Jun Jiang; Elliot Altman; Lisheng Wang; Ying Gao
Journal:  Oncol Lett       Date:  2017-06-23       Impact factor: 2.967

4.  Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines.

Authors:  Cheng-jian Tan; Yu Zhao; Masuo Goto; Kan-Yen Hsieh; Xiao-ming Yang; Susan L Morris-Natschke; Li-na Liu; Bao-yu Zhao; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem Lett       Date:  2015-09-05       Impact factor: 2.823

Review 5.  Anti-tumor activities of matrine and oxymatrine: literature review.

Authors:  Yan Liu; Yang Xu; Weidan Ji; Xiaoya Li; Bin Sun; Quangen Gao; Changqing Su
Journal:  Tumour Biol       Date:  2014-02-14

6.  Synthesis and biological evaluation of matrine derivatives containing benzo-α-pyrone structure as potent anti-lung cancer agents.

Authors:  Lichuan Wu; Guizhen Wang; Shuaibing Liu; Jinrui Wei; Sen Zhang; Ming Li; Guangbiao Zhou; Lisheng Wang
Journal:  Sci Rep       Date:  2016-10-27       Impact factor: 4.379

7.  Novel α, β-Unsaturated Sophoridinic Derivatives: Design, Synthesis, Molecular Docking and Anti-Cancer Activities.

Authors:  Yiming Xu; Lichuan Wu; Hang Dai; Mingyan Gao; Haroon Ur Rashid; Haodong Wang; Peng Xie; Xu Liu; Jun Jiang; Lisheng Wang
Journal:  Molecules       Date:  2017-11-14       Impact factor: 4.411

8.  Antiviral effect of matrine against human enterovirus 71.

Authors:  Yajun Yang; Jinghui Xiu; Xu Zhang; Liangfeng Zhang; Kai Yan; Chuan Qin; Jiangning Liu
Journal:  Molecules       Date:  2012-08-29       Impact factor: 4.411

9.  Synthesis, characterization and in vitro biological evaluation of two matrine derivatives.

Authors:  Xingan Cheng; Jingmin Ye; Huiqing He; Zhanmei Liu; Chunbao Charles Xu; Bo Wu; Xialing Xiong; Xugang Shu; Xuhong Jiang; Xiangjing Qin
Journal:  Sci Rep       Date:  2018-10-24       Impact factor: 4.379

10.  Synthesis, characterization and activity evaluation of matrinic acid derivatives as potential antiproliferative agents.

Authors:  Fan Chao; Dong-En Wang; Rui Liu; Qin Tu; Jian-Jun Liu; Jinyi Wang
Journal:  Molecules       Date:  2013-05-10       Impact factor: 4.411
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