Literature DB >> 22578240

Ryanodine receptor phosphorylation, calcium/calmodulin-dependent protein kinase II, and life-threatening ventricular arrhythmias.

Mark D McCauley1, Xander H T Wehrens.   

Abstract

Ryanodine receptor (RyR2) dysfunction, which may result from a variety of mechanisms, has been implicated in the pathogenesis of cardiac arrhythmias and heart failure. In this review, we discuss the important role of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in the regulation of RyR2-mediated Ca(2+) release. In particular, we examine how pathological activation of CaMKII can lead to an increased risk of sudden arrhythmic death. Finally, we discuss how reduction of CaMKII-mediated RyR2 hyperactivity might reduce the risk of arrhythmias and may serve as a rationale for future pharmacotherapeutic approaches.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 22578240      PMCID： PMC3356691          DOI： 10.1016/j.tcm.2012.02.004

Source DB:  PubMed          Journal:  Trends Cardiovasc Med        ISSN： 1050-1738            Impact factor:   6.677


  42 in total

1.  Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure.

Authors:  Ralph J van Oort; Mark D McCauley; Sayali S Dixit; Laetitia Pereira; Yi Yang; Jonathan L Respress; Qiongling Wang; Angela C De Almeida; Darlene G Skapura; Mark E Anderson; Donald M Bers; Xander H T Wehrens
Journal:  Circulation       Date:  2010-11-15       Impact factor: 29.690

2.  Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice.

Authors:  Jian Shan; Matthew J Betzenhauser; Alexander Kushnir; Steven Reiken; Albano C Meli; Anetta Wronska; Miroslav Dura; Bi-Xing Chen; Andrew R Marks
Journal:  J Clin Invest       Date:  2010-11-22       Impact factor: 14.808

3.  Differential cardiac remodeling in preload versus afterload.

Authors:  Karl Toischer; Adam G Rokita; Bernhard Unsöld; Wuqiang Zhu; Georgios Kararigas; Samuel Sossalla; Sean P Reuter; Alexander Becker; Nils Teucher; Tim Seidler; Cornelia Grebe; Lena Preuss; Shamindra N Gupta; Kathie Schmidt; Stephan E Lehnart; Martina Krüger; Wolfgang A Linke; Johannes Backs; Vera Regitz-Zagrosek; Katrin Schäfer; Loren J Field; Lars S Maier; Gerd Hasenfuss
Journal:  Circulation       Date:  2010-08-23       Impact factor: 29.690

4.  Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy.

Authors:  Satyam Sarma; Na Li; Ralph J van Oort; Corey Reynolds; Darlene G Skapura; Xander H T Wehrens
Journal:  Proc Natl Acad Sci U S A       Date:  2010-07-06       Impact factor: 11.205

5.  Reactive oxygen species-activated Ca/calmodulin kinase IIδ is required for late I(Na) augmentation leading to cellular Na and Ca overload.

Authors:  Stefan Wagner; Hanna M Ruff; Sarah L Weber; Sarah Bellmann; Thomas Sowa; Timo Schulte; Mark E Anderson; Eleonora Grandi; Donald M Bers; Johannes Backs; Luiz Belardinelli; Lars S Maier
Journal:  Circ Res       Date:  2011-01-20       Impact factor: 17.367

Review 6.  Ryanodine receptors: structure, expression, molecular details, and function in calcium release.

Authors:  Johanna T Lanner; Dimitra K Georgiou; Aditya D Joshi; Susan L Hamilton
Journal:  Cold Spring Harb Perspect Biol       Date:  2010-10-20       Impact factor: 10.005

7.  Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model.

Authors:  Ralph J van Oort; Jonathan L Respress; Na Li; Corey Reynolds; Angela C De Almeida; Darlene G Skapura; Leon J De Windt; Xander H T Wehrens
Journal:  Hypertension       Date:  2010-02-15       Impact factor: 10.190

8.  Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice.

Authors:  Mihail G Chelu; Satyam Sarma; Subeena Sood; Sufen Wang; Ralph J van Oort; Darlene G Skapura; Na Li; Marco Santonastasi; Frank Ulrich Müller; Wilhelm Schmitz; Ulrich Schotten; Mark E Anderson; Miguel Valderrábano; Dobromir Dobrev; Xander H T Wehrens
Journal:  J Clin Invest       Date:  2009-07       Impact factor: 14.808

9.  Critical role of nuclear calcium/calmodulin-dependent protein kinase IIdeltaB in cardiomyocyte survival in cardiomyopathy.

Authors:  Gillian H Little; Aman Saw; Yan Bai; Joan Dow; Paul Marjoram; Boris Simkhovich; Justin Leeka; Larry Kedes; Robert A Kloner; Coralie Poizat
Journal:  J Biol Chem       Date:  2009-07-14       Impact factor: 5.157

10.  Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass.

Authors:  Fredrick A Hilliard; Derek S Steele; Derek Laver; Zhaokang Yang; Sylvain J Le Marchand; Nagesh Chopra; David W Piston; Sabine Huke; Björn C Knollmann
Journal:  J Mol Cell Cardiol       Date:  2009-10-14       Impact factor: 5.000
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  12 in total

1.  Dantrolene: from better bacon to a treatment for ventricular fibrillation.

Authors:  Dan M Roden; Björn C Knollmann
Journal:  Circulation       Date:  2014-01-08       Impact factor: 29.690

2.  Reduced myocyte complex N-glycosylation causes dilated cardiomyopathy.

Authors:  Andrew R Ednie; Wei Deng; Kay-Pong Yip; Eric S Bennett
Journal:  FASEB J       Date:  2018-08-23       Impact factor: 5.191

3.  CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome.

Authors:  Sean DeGrande; Derek Nixon; Olha Koval; Jerald W Curran; Patrick Wright; Qiongling Wang; Farshid Kashef; David Chiang; Na Li; Xander H T Wehrens; Mark E Anderson; Thomas J Hund; Peter J Mohler
Journal:  Heart Rhythm       Date:  2012-08-28       Impact factor: 6.343

Review 4.  Chasing cardiac physiology and pathology down the CaMKII cascade.

Authors:  Alicia Mattiazzi; Rosana A Bassani; Ariel L Escobar; Julieta Palomeque; Carlos A Valverde; Martín Vila Petroff; Donald M Bers
Journal:  Am J Physiol Heart Circ Physiol       Date:  2015-03-06       Impact factor: 4.733

Review 5.  Calcium Signaling and Cardiac Arrhythmias.

Authors:  Andrew P Landstrom; Dobromir Dobrev; Xander H T Wehrens
Journal:  Circ Res       Date:  2017-06-09       Impact factor: 17.367

Review 6.  Alterations in ryanodine receptors and related proteins in heart failure.

Authors:  Sameer Ather; Jonathan L Respress; Na Li; Xander H T Wehrens
Journal:  Biochim Biophys Acta       Date:  2013-06-14

7.  Role of RyR2 phosphorylation in heart failure and arrhythmias: Controversies around ryanodine receptor phosphorylation in cardiac disease.

Authors:  Dobromir Dobrev; Xander H T Wehrens
Journal:  Circ Res       Date:  2014-04-11       Impact factor: 17.367

8.  Hyperphosphorylation of RyRs underlies triggered activity in transgenic rabbit model of LQT2 syndrome.

Authors:  Dmitry Terentyev; Colin M Rees; Weiyan Li; Leroy L Cooper; Hitesh K Jindal; Xuwen Peng; Yichun Lu; Radmila Terentyeva; Katja E Odening; Jean Daley; Kamana Bist; Bum-Rak Choi; Alain Karma; Gideon Koren
Journal:  Circ Res       Date:  2014-09-23       Impact factor: 17.367

9.  The Concise Guide to PHARMACOLOGY 2013/14: ion channels.

Authors:  Stephen P H Alexander; Helen E Benson; Elena Faccenda; Adam J Pawson; Joanna L Sharman; William A Catterall; Michael Spedding; John A Peters; Anthony J Harmar
Journal:  Br J Pharmacol       Date:  2013-12       Impact factor: 8.739

Review 10.  Mechanisms underlying pathological Ca2+ handling in diseases of the heart.

Authors:  Satadru K Lahiri; Yuriana Aguilar-Sanchez; Xander H T Wehrens
Journal:  Pflugers Arch       Date:  2021-01-05       Impact factor: 3.657
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