Literature DB >> 22577819

How should we think about the ribosome?

Peter B Moore1.   

Abstract

In a few years we are likely to have structures for the ribosome in all the conformations it assumes during protein synthesis. The golden age of ribosome structure determination is thus drawing to a close, and as it does the focus in the field will shift from structure determination to understanding why the ribosome's structure changes the way it does as it performs its function. Thus in the future, kinetic and thermodynamic experiments will become increasingly important, and as they do, the field will have to start thinking about the dynamics of the ribosome far more carefully than it has in the past. The reasoning that underlies these assertions will be explained, and a more general issue explored, namely what can be said today about the modus operandi of the ribosome. What kind of a device is it?

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Year:  2012        PMID: 22577819     DOI: 10.1146/annurev-biophys-050511-102314

Source DB:  PubMed          Journal:  Annu Rev Biophys        ISSN: 1936-122X            Impact factor:   12.981


  37 in total

1.  Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.

Authors:  Nelson B Olivier; Roger B Altman; Jonas Noeske; Gregory S Basarab; Erin Code; Andrew D Ferguson; Ning Gao; Jian Huang; Manuel F Juette; Stephania Livchak; Matthew D Miller; D Bryan Prince; Jamie H D Cate; Ed T Buurman; Scott C Blanchard
Journal:  Proc Natl Acad Sci U S A       Date:  2014-11-03       Impact factor: 11.205

2.  EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome.

Authors:  Dejiu Zhang; Kaige Yan; Guangqiao Liu; Guangtao Song; Jiejian Luo; Yi Shi; Erchao Cheng; Shan Wu; Taijiao Jiang; Jizhong Lou; Ning Gao; Yan Qin
Journal:  Nat Struct Mol Biol       Date:  2016-01-25       Impact factor: 15.369

3.  Irrelevance of the power stroke for the directionality, stopping force, and optimal efficiency of chemically driven molecular machines.

Authors:  R Dean Astumian
Journal:  Biophys J       Date:  2015-01-20       Impact factor: 4.033

4.  Conformational landscape of a virus by single-particle X-ray scattering.

Authors:  Ahmad Hosseinizadeh; Ghoncheh Mashayekhi; Jeremy Copperman; Peter Schwander; Ali Dashti; Reyhaneh Sepehr; Russell Fung; Marius Schmidt; Chun Hong Yoon; Brenda G Hogue; Garth J Williams; Andrew Aquila; Abbas Ourmazd
Journal:  Nat Methods       Date:  2017-08-14       Impact factor: 28.547

5.  Microscopic reversibility as the organizing principle of molecular machines.

Authors:  R Dean Astumian
Journal:  Nat Nanotechnol       Date:  2012-11       Impact factor: 39.213

Review 6.  Bacterial replication, transcription and translation: mechanistic insights from single-molecule biochemical studies.

Authors:  Andrew Robinson; Antoine M van Oijen
Journal:  Nat Rev Microbiol       Date:  2013-04-03       Impact factor: 60.633

7.  Structure of Ribosomal Silencing Factor Bound to Mycobacterium tuberculosis Ribosome.

Authors:  Xiaojun Li; Qingan Sun; Cai Jiang; Kailu Yang; Li-Wei Hung; Junjie Zhang; James C Sacchettini
Journal:  Structure       Date:  2015-08-20       Impact factor: 5.006

8.  A frameshifting stimulatory stem loop destabilizes the hybrid state and impedes ribosomal translocation.

Authors:  Hee-Kyung Kim; Fei Liu; Jingyi Fei; Carlos Bustamante; Ruben L Gonzalez; Ignacio Tinoco
Journal:  Proc Natl Acad Sci U S A       Date:  2014-03-31       Impact factor: 11.205

9.  Characterizing inactive ribosomes in translational profiling.

Authors:  Botao Liu; Shu-Bing Qian
Journal:  Translation (Austin)       Date:  2016-01-08

Review 10.  Why nature really chose phosphate.

Authors:  Shina C L Kamerlin; Pankaz K Sharma; Ram B Prasad; Arieh Warshel
Journal:  Q Rev Biophys       Date:  2013-01-15       Impact factor: 5.318

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