| Literature DB >> 2257744 |
S s Riar1, C Devakumar, G Ilavazhagan, J Bardhan, A K Kain, P Thomas, R Singh, B Singh.
Abstract
The volatile, odorous fraction of neem oil coded as NIM-76 obtained by steam distillation was investigated for in vitro spermicidal activity. The data showed that the minimum concentration which inhibited spermatozoal motility was 0.25 mg/ml for rat and 25 mg/ml for human spermatozoa. The effect of the drug on spermatozoal motility was found to be dose-dependent. The activity of this drug was not altered in the presence of vaginal or cervical mucus. Intra-vaginal application of NIM-76 in rabbits showed no irritation to the vaginal mucosa.Entities:
Mesh：
Substances：
Year: 1990 PMID： 2257744 DOI： 10.1016/0010-7824(90)90054-y
Source DB: PubMed Journal: Contraception ISSN： 0010-7824 Impact factor: 3.375