BACKGROUND: Improved survival with chronic liver disease (CLD) and increased incidence in the older has led to a rapidly expanding population which faces similar "geriatric syndromes" as the general population. With risk factors such as autonomic dysfunction, cognitive impairment, and muscle abnormalities in CLD it is expected that falls and injury will be common. AIM: To determine prevalence of falls and injury in chronic liver disease and to identify potential modifiable fall associations. METHODS: Falls prevalence was estimated by providing patients aged ≥ 65 years with CLD a falls data collection tool, via the post or in the clinic. A younger CLD cohort and age-matched and sex-matched community controls was used for comparison. A sub-group underwent multidisciplinary falls assessment to identify modifiable fall associations. RESULTS: Falls were significantly more common in older people with CLD (47 % in previous year) than in controls; incidence of injury did not differ. Regression identified orthostatic symptoms, lower-limb strength, and fear of falling as being independently associated with falls in CLD. Those who had fallen had significantly greater difficulty with daily activities. CONCLUSION: Falls are prevalent in older people with CLD, and are potentially preventable with multifactorial intervention. Services must prepare for expansion in the older CLD population; here we demonstrate how this expansion may affect falls services and provide a potential therapeutic target.
BACKGROUND: Improved survival with chronic liver disease (CLD) and increased incidence in the older has led to a rapidly expanding population which faces similar "geriatric syndromes" as the general population. With risk factors such as autonomic dysfunction, cognitive impairment, and muscle abnormalities in CLD it is expected that falls and injury will be common. AIM: To determine prevalence of falls and injury in chronic liver disease and to identify potential modifiable fall associations. METHODS: Falls prevalence was estimated by providing patients aged ≥ 65 years with CLD a falls data collection tool, via the post or in the clinic. A younger CLD cohort and age-matched and sex-matched community controls was used for comparison. A sub-group underwent multidisciplinary falls assessment to identify modifiable fall associations. RESULTS: Falls were significantly more common in older people with CLD (47 % in previous year) than in controls; incidence of injury did not differ. Regression identified orthostatic symptoms, lower-limb strength, and fear of falling as being independently associated with falls in CLD. Those who had fallen had significantly greater difficulty with daily activities. CONCLUSION: Falls are prevalent in older people with CLD, and are potentially preventable with multifactorial intervention. Services must prepare for expansion in the older CLD population; here we demonstrate how this expansion may affect falls services and provide a potential therapeutic target.
Authors: Christine Schrezenmaier; Jade A Gehrking; Stacy M Hines; Phillip A Low; Lisa M Benrud-Larson; Paola Sandroni Journal: Mayo Clin Proc Date: 2005-03 Impact factor: 7.616
Authors: Julia L Newton; Kieren G Hollingsworth; Roy Taylor; Ahmed M El-Sharkawy; Zia Uda Khan; Ruth Pearce; Kathryn Sutcliffe; Oke Okonkwo; Adrian Davidson; Jennifer Burt; Andrew M Blamire; David Jones Journal: Hepatology Date: 2008-08 Impact factor: 17.425
Authors: Kieren G Hollingsworth; Julia L Newton; Roy Taylor; Claire McDonald; Jeremy M Palmer; Andrew M Blamire; David E J Jones Journal: Clin Gastroenterol Hepatol Date: 2008-08-08 Impact factor: 11.382