Literature DB >> 22576441

Leishmanicidal compounds from the fruits of Piper longum.

Sabari Ghosal1, Anindita Deb, Priyanka Mishra, Ram Vishwakarma.   

Abstract

One new alkaloid amide, piperlongumide (1) [N-isobutyl-19-(3',4'-methylenedioxyphenyl)-2E,4E nonadecadienamide], and six known compounds with leishmanicidal activity against promastigotes and axenic amastigotes of Leishmania donovani were isolated from the n-hexane fraction of the fruits of Piper longum. The structure of 1 was elucidated by spectroscopic evidences. Georg Thieme Verlag KG Stuttgart · New York.

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Year:  2012        PMID： 22576441     DOI： 10.1055/s-0031-1298537

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  4 in total

Review 1.  Potential of Piper spp. as a source of new compounds for the leishmaniases treatment.

Authors:  Juliana Figueiredo Peixoto; Ygor Jessé Ramos; Davyson de Lima Moreira; Carlos Roberto Alves; Luiz Filipe Gonçalves-Oliveira
Journal:  Parasitol Res       Date:  2021-07-10       Impact factor: 2.289

2.  Leishmania donovani pteridine reductase 1: comparative protein modeling and protein-ligand interaction studies of the leishmanicidal constituents isolated from the fruits of Piper longum.

Authors:  Shakti Sahi; Parul Tewatia; Sabari Ghosal
Journal:  J Mol Model       Date:  2012-07-03       Impact factor: 1.810

Review 3.  The Search for Putative Hits in Combating Leishmaniasis: The Contributions of Natural Products Over the Last Decade.

Authors:  Patrick O Sakyi; Richard K Amewu; Robert N O A Devine; Emahi Ismaila; Whelton A Miller; Samuel K Kwofie
Journal:  Nat Prod Bioprospect       Date:  2021-07-14

4.  Antiparasitic Activity and Essential Oil Chemical Analysis of the Piper Tuberculatum Jacq Fruit.

Authors:  Valterlúcio Dos Santos Sales; Álefe Brito Monteiro; Gyllyandeson de Araújo Delmondes; Emmily Petícia do Nascimento; Francisco Rodolpho Sobreira Dantas Nóbrega de Figuêiredo; Cristina Kelly de Souza Rodrigues; Josefa Fernanda Evangelista de Lacerda; Cícera Norma Fernandes; Maysa de Oliveira Barbosa; Adamo Xenofonte Brasil; Saulo Relison Tintino; Maria Celeste Vega Gomez; Cathia Coronel; Henrique Douglas Melo Coutinho; José Galberto Martins da Costa; Cícero Francisco Bezerra Felipe; Irwin Rose Alencar de Menezes; Marta Regina Kerntopf
Journal:  Iran J Pharm Res       Date:  2018       Impact factor: 1.696
  4 in total

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