| Literature DB >> 22575869 |
Bénédicte Delouvrié1, Katherine Al-Kadhimi, Jean-Claude Arnould, Simon T Barry, Darren A E Cross, Myriam Didelot, Paul R Gavine, Hervé Germain, Craig S Harris, Adina M Hughes, David A Jude, Jane Kendrew, Christine Lambert-van der Brempt, Jean-Jacques Lohmann, Morgan Ménard, Andrew A Mortlock, Martin Pass, Claire Rooney, Michel Vautier, Jennifer L Vincent, Nicolas Warin.
Abstract
Potent antagonists of the integrin α(5)β(1), which are RGD mimetics built from tyrosine are described. This letter describes the optimization of in vitro potency obtained by variation of two parts of the molecule, the basic group and the linker between the basic group and the phenyl central core.Entities:
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Year: 2012 PMID： 22575869 DOI： 10.1016/j.bmcl.2012.04.063
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823