| Literature DB >> 22575214 |
Pablo H Strobl-Mazzulla1, Marianne E Bronner.
Abstract
The epithelial-to-mesenchymal transition (EMT) is an important event converting compact and ordered epithelial cells into migratory mesenchymal cells. Given the molecular and cellular similarities between pathological and developmental EMTs, studying this event during neural crest development offers and excellent in vivo model for understanding the mechanisms underlying this process. Here, we review new and old insight into neural crest EMT in search of commonalities with cancer progression that might aid in the design of specific therapeutic prevention.Entities:
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Year: 2012 PMID: 22575214 PMCID: PMC3435443 DOI: 10.1016/j.semcancer.2012.04.008
Source DB: PubMed Journal: Semin Cancer Biol ISSN: 1044-579X Impact factor: 15.707