Literature DB >> 22573721

European perspective on multiple myeloma treatment strategies: update following recent congresses.

Heinz Ludwig1, Hervé Avet-Loiseau, Joan Bladé, Mario Boccadoro, Jamie Cavenagh, Michele Cavo, Faith Davies, Javier de la Rubia, Sosana Delimpasi, Meletios Dimopoulos, Johannes Drach, Hermann Einsele, Thierry Facon, Hartmut Goldschmidt, Urs Hess, Ulf-Henrik Mellqvist, Philippe Moreau, Jesús San-Miguel, Pia Sondergeld, Pieter Sonneveld, Miklos Udvardy, Antonio Palumbo.   

Abstract

The management of multiple myeloma has undergone profound changes over the recent past as a result of advances in our understanding of the disease biology as well as improvements in treatment and supportive care strategies. Notably, recent years have seen a surge in studies incorporating the novel agents thalidomide, bortezomib, and lenalidomide into treatment for different disease stages and across different patient groups. This article presents an update to a previous review of European treatment practices and is based on discussions during an expert meeting that was convened to review novel agent data published or presented at medical meetings until the end of 2011 and to assess their impact on treatment strategies.

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Year:  2012        PMID: 22573721      PMCID: PMC3360899          DOI: 10.1634/theoncologist.2011-0391

Source DB:  PubMed          Journal:  Oncologist        ISSN: 1083-7159


  98 in total

1.  Can multiple myeloma become a curable disease?

Authors:  Jesús F San-Miguel; María-Victoria Mateos
Journal:  Haematologica       Date:  2011-09       Impact factor: 9.941

2.  Impact of gene expression profiling-based risk stratification in patients with myeloma receiving initial therapy with lenalidomide and dexamethasone.

Authors:  Shaji K Kumar; Hajime Uno; Susanna J Jacobus; Scott A Van Wier; Greg J Ahmann; Kimberly J Henderson; Natalie S Callander; Jessica L Haug; David S Siegel; Philip R Greipp; Rafael Fonseca; S Vincent Rajkumar
Journal:  Blood       Date:  2011-08-22       Impact factor: 22.113

3.  Thalidomide for previously untreated elderly patients with multiple myeloma: meta-analysis of 1685 individual patient data from 6 randomized clinical trials.

Authors:  Peter M Fayers; Antonio Palumbo; Cyrille Hulin; Anders Waage; Pierre Wijermans; Meral Beksaç; Sara Bringhen; Jean-Yves Mary; Peter Gimsing; Fabian Termorshuizen; Rauf Haznedar; Tommaso Caravita; Philippe Moreau; Ingemar Turesson; Pellegrino Musto; Lotfi Benboubker; Martijn Schaafsma; Pieter Sonneveld; Thierry Facon
Journal:  Blood       Date:  2011-06-13       Impact factor: 22.113

4.  Efficacy of retreatment with immunomodulatory drugs (IMiDs) in patients receiving IMiDs for initial therapy of newly diagnosed multiple myeloma.

Authors:  Sumit Madan; Martha Q Lacy; Angela Dispenzieri; Morie A Gertz; Francis Buadi; Suzanne R Hayman; Kristen Detweiler-Short; David Dingli; Steven Zeldenrust; John Lust; Philip R Greipp; S Vincent Rajkumar; Shaji Kumar
Journal:  Blood       Date:  2011-06-14       Impact factor: 22.113

5.  Cyclophosphamide, thalidomide, and dexamethasone (CTD) as initial therapy for patients with multiple myeloma unsuitable for autologous transplantation.

Authors:  Gareth J Morgan; Faith E Davies; Walter M Gregory; Nigel H Russell; Sue E Bell; Alexander J Szubert; Nuria Navarro Coy; Gordon Cook; Sylvia Feyler; Jenny L Byrne; Huw Roddie; Claudius Rudin; Mark T Drayson; Roger G Owen; Fiona M Ross; Graham H Jackson; J Anthony Child
Journal:  Blood       Date:  2011-06-07       Impact factor: 22.113

6.  Genetic factors underlying the risk of bortezomib induced peripheral neuropathy in multiple myeloma patients.

Authors:  Sophie L Corthals; Rowan Kuiper; David C Johnson; Pieter Sonneveld; Roman Hajek; Bronno van der Holt; Florence Magrangeas; Hartmut Goldschmidt; Gareth J Morgan; Hervé Avet-Loiseau
Journal:  Haematologica       Date:  2011-07-26       Impact factor: 9.941

7.  Approach to the treatment of multiple myeloma: a clash of philosophies.

Authors:  S Vincent Rajkumar; Gösta Gahrton; P Leif Bergsagel
Journal:  Blood       Date:  2011-07-25       Impact factor: 22.113

8.  Increased serum lactate dehydrongenase should be included among the variables that define very-high-risk multiple myeloma.

Authors:  Maria Gkotzamanidou; Efstathios Kastritis; Maria Roussou Magdalini Migkou Maria Gavriatopoulou; Nikitas Nikitas; Dimitra Gika; Despina Mparmparousi; Charis Matsouka; Evangelos Terpos; Meletios A Dimopoulos
Journal:  Clin Lymphoma Myeloma Leuk       Date:  2011-09-08

Review 9.  Personalized therapy in multiple myeloma according to patient age and vulnerability: a report of the European Myeloma Network (EMN).

Authors:  Antonio Palumbo; Sara Bringhen; Heinz Ludwig; Meletios A Dimopoulos; Joan Bladé; Maria V Mateos; Laura Rosiñol; Mario Boccadoro; Michele Cavo; Henk Lokhorst; Sonja Zweegman; Evangelos Terpos; Faith Davies; Christoph Driessen; Peter Gimsing; Martin Gramatzki; Roman Hàjek; Hans E Johnsen; Fernando Leal Da Costa; Orhan Sezer; Andrew Spencer; Meral Beksac; Gareth Morgan; Hermann Einsele; Jesus F San Miguel; Pieter Sonneveld
Journal:  Blood       Date:  2011-08-12       Impact factor: 22.113

Review 10.  Treatment of multiple myeloma.

Authors:  S Vincent Rajkumar
Journal:  Nat Rev Clin Oncol       Date:  2011-04-26       Impact factor: 66.675

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  15 in total

Review 1.  European perspective on multiple myeloma treatment strategies in 2014.

Authors:  Heinz Ludwig; Pieter Sonneveld; Faith Davies; Joan Bladé; Mario Boccadoro; Michele Cavo; Gareth Morgan; Javier de la Rubia; Michel Delforge; Meletios Dimopoulos; Hermann Einsele; Thierry Facon; Hartmut Goldschmidt; Philippe Moreau; Hareth Nahi; Torben Plesner; Jesús San-Miguel; Roman Hajek; Pia Sondergeld; Antonio Palumbo
Journal:  Oncologist       Date:  2014-07-25

Review 2.  International Myeloma Working Group recommendations for global myeloma care.

Authors:  H Ludwig; J S Miguel; M A Dimopoulos; A Palumbo; R Garcia Sanz; R Powles; S Lentzsch; W Ming Chen; J Hou; A Jurczyszyn; K Romeril; R Hajek; E Terpos; K Shimizu; D Joshua; V Hungria; A Rodriguez Morales; D Ben-Yehuda; P Sondergeld; E Zamagni; B Durie
Journal:  Leukemia       Date:  2013-10-09       Impact factor: 11.528

3.  Impaired efferocytosis by monocytes in multiple myeloma.

Authors:  Ying Yu Liang; Ilse Schwarzinger; Ingrid Simonitsch-Klupp; Hermine Agis; Rudolf Oehler
Journal:  Oncol Lett       Date:  2018-05-02       Impact factor: 2.967

4.  Autologous stem cell transplantation versus novel drugs or conventional chemotherapy for patients with relapsed multiple myeloma after previous ASCT.

Authors:  M Grövdal; H Nahi; G Gahrton; J Liwing; A Waage; N Abildgaard; P T Pedersen; J Hammerstrøm; A Laaksonen; P Bazia; V Terava; H Ollikainen; R Silvennoinen; M Putkonen; P Anttila; K Porkka; K Remes
Journal:  Bone Marrow Transplant       Date:  2015-04-13       Impact factor: 5.483

Review 5.  Current treatment landscape for relapsed and/or refractory multiple myeloma.

Authors:  Meletios A Dimopoulos; Paul G Richardson; Philippe Moreau; Kenneth C Anderson
Journal:  Nat Rev Clin Oncol       Date:  2014-11-25       Impact factor: 66.675

6.  Novel agents have a significant impact on survival of patients with multiple myeloma.

Authors:  Wolfgang Lamm; Sandra Eder; Marija Bojic; Christoph C Zielinski; Johannes Drach
Journal:  Wien Klin Wochenschr       Date:  2015-01-22       Impact factor: 1.704

7.  Overcoming the response plateau in multiple myeloma: a novel bortezomib-based strategy for secondary induction and high-yield CD34+ stem cell mobilization.

Authors:  Ruben Niesvizky; Tomer M Mark; Maureen Ward; David S Jayabalan; Roger N Pearse; Megan Manco; Jessica Stern; Paul J Christos; Lena Mathews; Tsiporah B Shore; Faiza Zafar; Karen Pekle; Zhaoying Xiang; Scott Ely; Donna Skerret; Selina Chen-Kiang; Morton Coleman; Maureen E Lane
Journal:  Clin Cancer Res       Date:  2013-01-28       Impact factor: 12.531

Review 8.  Incorporating novel agents in the management of elderly myeloma patients.

Authors:  Tommasina Guglielmelli; Antonio Palumbo
Journal:  Curr Hematol Malig Rep       Date:  2013-12       Impact factor: 4.213

9.  mTOR pathway activation in multiple myeloma cell lines and primary tumour cells: pomalidomide enhances cytoplasmic-nuclear shuttling of mTOR protein.

Authors:  Tommasina Guglielmelli; Emilia Giugliano; Vanessa Brunetto; Ida Rapa; Susanna Cappia; Jessica Giorcelli; Sokol Rrodhe; Mauro Papotti; Giuseppe Saglio
Journal:  Oncoscience       Date:  2015-04-06

10.  Efficacy and tolerability of bendamustine, bortezomib and dexamethasone in patients with relapsed-refractory multiple myeloma: a phase II study.

Authors:  M Offidani; L Corvatta; L Maracci; A M Liberati; S Ballanti; I Attolico; P Caraffa; F Alesiani; T Caravita di Toritto; S Gentili; P Tosi; M Brunori; D Derudas; A Ledda; A Gozzetti; C Cellini; L Malerba; A Mele; A Andriani; S Galimberti; P Mondello; S Pulini; U Coppetelli; P Fraticelli; A Olivieri; P Leoni
Journal:  Blood Cancer J       Date:  2013-11-22       Impact factor: 11.037

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