Literature DB >> 22573589

Resistance to voriconazole due to a G448S substitution in Aspergillus fumigatus in a patient with cerebral aspergillosis.

Teresa Pelaez1, Paloma Gijón, Eleonora Bunsow, Emilio Bouza, Waldo Sánchez-Yebra, Maricela Valerio, Beatriz Gama, Manuel Cuenca-Estrella, Emilia Mellado.   

Abstract

A voriconazole-resistant isolate of Aspergillus fumigatus was recovered from an immunocompetent patient receiving long-term antifungal therapy for cerebral aspergillosis. A G448S amino acid substitution in the azole target (Cyp51A) was identified as the cause of the resistance phenotype. This article describes the first isolation of a voriconazole-resistant A. fumigatus isolate from an immunocompetent patient in Spain.

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Year:  2012        PMID： 22573589      PMCID： PMC3405584          DOI： 10.1128/JCM.00329-12

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  31 in total

1.  EUCAST Technical Note on the method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for conidia-forming moulds.

Authors: 
Journal:  Clin Microbiol Infect       Date:  2008-10       Impact factor: 8.067

2.  Wild-type MIC distributions and epidemiological cutoff values for the triazoles and six Aspergillus spp. for the CLSI broth microdilution method (M38-A2 document).

Authors:  A Espinel-Ingroff; D J Diekema; A Fothergill; E Johnson; T Pelaez; M A Pfaller; M G Rinaldi; E Canton; J Turnidge
Journal:  J Clin Microbiol       Date:  2010-06-30       Impact factor: 5.948

3.  Invasive fungal infections among organ transplant recipients: results of the Transplant-Associated Infection Surveillance Network (TRANSNET).

Authors:  Peter G Pappas; Barbara D Alexander; David R Andes; Susan Hadley; Carol A Kauffman; Alison Freifeld; Elias J Anaissie; Lisa M Brumble; Loreen Herwaldt; James Ito; Dimitrios P Kontoyiannis; G Marshall Lyon; Kieren A Marr; Vicki A Morrison; Benjamin J Park; Thomas F Patterson; Trish M Perl; Robert A Oster; Mindy G Schuster; Randall Walker; Thomas J Walsh; Kathleen A Wannemuehler; Tom M Chiller
Journal:  Clin Infect Dis       Date:  2010-04-15       Impact factor: 9.079

4.  Acquired resistance to voriconazole and itraconazole in a patient with pulmonary aspergilloma.

Authors:  Bahrie Bellete; Helene Raberin; Jerome Morel; Pierre Flori; Jamal Hafid; Roger Tran Manhsung
Journal:  Med Mycol       Date:  2010-02       Impact factor: 4.076

5.  Development of azole resistance in Aspergillus fumigatus during azole therapy associated with change in virulence.

Authors:  Maiken Cavling Arendrup; Eleftheria Mavridou; Klaus Leth Mortensen; Eveline Snelders; Niels Frimodt-Møller; Humara Khan; Willem J G Melchers; Paul E Verweij
Journal:  PLoS One       Date:  2010-04-09       Impact factor: 3.240

6.  Azole resistance in Aspergillus fumigatus: a side-effect of environmental fungicide use?

Authors:  Paul E Verweij; Eveline Snelders; Gert H J Kema; Emilia Mellado; Willem J G Melchers
Journal:  Lancet Infect Dis       Date:  2009-12       Impact factor: 25.071

7.  Aspergillus section Fumigati: antifungal susceptibility patterns and sequence-based identification.

Authors:  Laura Alcazar-Fuoli; Emilia Mellado; Ana Alastruey-Izquierdo; Manuel Cuenca-Estrella; Juan L Rodriguez-Tudela
Journal:  Antimicrob Agents Chemother       Date:  2008-01-22       Impact factor: 5.191

8.  Epidemiological cutoffs and cross-resistance to azole drugs in Aspergillus fumigatus.

Authors:  Juan Luis Rodriguez-Tudela; Laura Alcazar-Fuoli; Emilia Mellado; Ana Alastruey-Izquierdo; Araceli Monzon; Manuel Cuenca-Estrella
Journal:  Antimicrob Agents Chemother       Date:  2008-05-12       Impact factor: 5.191

9.  Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure.

Authors:  Susan J Howard; Dasa Cerar; Michael J Anderson; Ahmed Albarrag; Matthew C Fisher; Alessandro C Pasqualotto; Michel Laverdiere; Maiken C Arendrup; David S Perlin; David W Denning
Journal:  Emerg Infect Dis       Date:  2009-07       Impact factor: 6.883

10.  Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism.

Authors:  Eveline Snelders; Henrich A L van der Lee; Judith Kuijpers; Anthonius J M M Rijs; János Varga; Robert A Samson; Emilia Mellado; A Rogier T Donders; Willem J G Melchers; Paul E Verweij
Journal:  PLoS Med       Date:  2008-11-11       Impact factor: 11.069
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  19 in total

1.  Investigation of Multiple Resistance Mechanisms in Voriconazole-Resistant Aspergillus flavus Clinical Isolates from a Chest Hospital Surveillance in Delhi, India.

Authors:  Cheshta Sharma; Rakesh Kumar; Nitin Kumar; Aradhana Masih; Dinesh Gupta; Anuradha Chowdhary
Journal:  Antimicrob Agents Chemother       Date:  2018-02-23       Impact factor: 5.191

2.  Characterization of Aspergillus fumigatus cross-resistance between clinical and DMI azole drugs.

Authors:  Rocio Garcia-Rubio; Irene Gonzalez-Jimenez; Jose Lucio; Emilia Mellado
Journal:  Appl Environ Microbiol       Date:  2020-12-18       Impact factor: 4.792

3.  Molecular Identification and Susceptibility Testing of Molds Isolated in a Prospective Surveillance of Triazole Resistance in Spain (FILPOP2 Study).

Authors:  Ana Alastruey-Izquierdo; Laura Alcazar-Fuoli; Olga Rivero-Menéndez; Josefina Ayats; Carmen Castro; Julio García-Rodríguez; Lidia Goterris-Bonet; Elisa Ibáñez-Martínez; María José Linares-Sicilia; M Teresa Martin-Gomez; Estrella Martín-Mazuelos; Teresa Pelaez; Javier Peman; Antonio Rezusta; Susana Rojo; Rocio Tejero; Diego Vicente Anza; Jesús Viñuelas; Maria Soledad Zapico; Manuel Cuenca-Estrella
Journal:  Antimicrob Agents Chemother       Date:  2018-08-27       Impact factor: 5.191

Review 4.  Aspergillus fumigatus and aspergillosis: From basics to clinics.

Authors:  A Arastehfar; A Carvalho; J Houbraken; L Lombardi; R Garcia-Rubio; J D Jenks; O Rivero-Menendez; R Aljohani; I D Jacobsen; J Berman; N Osherov; M T Hedayati; M Ilkit; D James-Armstrong; T Gabaldón; J Meletiadis; M Kostrzewa; W Pan; C Lass-Flörl; D S Perlin; M Hoenigl
Journal:  Stud Mycol       Date:  2021-05-10       Impact factor: 16.097

5.  Is azole resistance in Aspergillus fumigatus a problem in Spain?

Authors:  Pilar Escribano; Teresa Peláez; Patricia Muñoz; Emilio Bouza; Jesús Guinea
Journal:  Antimicrob Agents Chemother       Date:  2013-04-29       Impact factor: 5.191

6.  Evolution of cross-resistance to medical triazoles in Aspergillus fumigatus through selection pressure of environmental fungicides.

Authors:  Jianhua Zhang; Joost van den Heuvel; Alfons J M Debets; Paul E Verweij; Willem J G Melchers; Bas J Zwaan; Sijmen E Schoustra
Journal:  Proc Biol Sci       Date:  2017-09-27       Impact factor: 5.349

7.  Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14α-Demethylase.

Authors:  Alia A Sagatova; Mikhail V Keniya; Joel D A Tyndall; Brian C Monk
Journal:  Antimicrob Agents Chemother       Date:  2018-02-23       Impact factor: 5.191

8.  An invisible threat: mutation-mediated resistance to triazole drugs in Aspergillus.

Authors:  Cau D Pham; Shawn R Lockhart
Journal:  Curr Fungal Infect Rep       Date:  2012-12-16

9.  Candida tropicalis antifungal cross-resistance is related to different azole target (Erg11p) modifications.

Authors:  A Forastiero; A C Mesa-Arango; A Alastruey-Izquierdo; L Alcazar-Fuoli; L Bernal-Martinez; T Pelaez; J F Lopez; J O Grimalt; A Gomez-Lopez; I Cuesta; O Zaragoza; E Mellado
Journal:  Antimicrob Agents Chemother       Date:  2013-07-22       Impact factor: 5.191

10.  Development and Validation of a High-Resolution Melting Assay To Detect Azole Resistance in Aspergillus fumigatus.

Authors:  L Bernal-Martínez; H Gil; O Rivero-Menéndez; S Gago; M Cuenca-Estrella; E Mellado; A Alastruey-Izquierdo
Journal:  Antimicrob Agents Chemother       Date:  2017-11-22       Impact factor: 5.191
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