BACKGROUND: This study was undertaken to evaluate the association of the E23K polymorphism of KCNJ11 and type 1 diabetes in a Korean population. METHODS: Clinical variables from 70 Korean children with type 1 diabetes were analyzed. Patients' DNA was screened for the E23 locus in the KCNJ11 gene. Each genotype frequency and clinical characteristics according to the genotypes were compared between the patient and control groups. RESULTS: The genotype frequencies of the KCNJ11 E23 polymorphic locus in the patient group were 30.0% for EE, 44.3% for EK, and 25.7% for KK. We detected no differences in genotype frequencies between the patient and control groups. Additionally, in the patient group, no difference was detected in the clinical phenotypes among the three genotypes. CONCLUSION: Although a rather small sample size constituted a limitation of this study, the association of the E23K polymorphism with type 1 diabetes was not statistically significant in the Korean population evaluated.
BACKGROUND: This study was undertaken to evaluate the association of the E23K polymorphism of KCNJ11 and type 1 diabetes in a Korean population. METHODS: Clinical variables from 70 Korean children with type 1 diabetes were analyzed. Patients' DNA was screened for the E23 locus in the KCNJ11 gene. Each genotype frequency and clinical characteristics according to the genotypes were compared between the patient and control groups. RESULTS: The genotype frequencies of the KCNJ11 E23 polymorphic locus in the patient group were 30.0% for EE, 44.3% for EK, and 25.7% for KK. We detected no differences in genotype frequencies between the patient and control groups. Additionally, in the patient group, no difference was detected in the clinical phenotypes among the three genotypes. CONCLUSION: Although a rather small sample size constituted a limitation of this study, the association of the E23K polymorphism with type 1 diabetes was not statistically significant in the Korean population evaluated.
Authors: Jose C Florez; Kathleen A Jablonski; Steven E Kahn; Paul W Franks; Dana Dabelea; Richard F Hamman; William C Knowler; David M Nathan; David Altshuler Journal: Diabetes Date: 2007-02 Impact factor: 9.461
Authors: Daizhan Zhou; Di Zhang; Yun Liu; Teng Zhao; Zhuo Chen; Zhe Liu; Lan Yu; Zuofeng Zhang; He Xu; Lin He Journal: J Hum Genet Date: 2009-06-05 Impact factor: 3.172
Authors: Christina Eftychi; Joanna M M Howson; Bryan J Barratt; Adrian Vella; Felicity Payne; Deborah J Smyth; Rebecca C J Twells; Neil M Walker; Helen E Rance; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; Dag E Undlien; Kjersti S Rønningen; Cristian Guja; Constantin Ionescu-Tîirgovişte; David A Savage; John A Todd Journal: Diabetes Date: 2004-03 Impact factor: 9.461
Authors: S M Raj; J M M Howson; N M Walker; J D Cooper; D J Smyth; S F Field; H E Stevens; J A Todd Journal: Diabetologia Date: 2009-05-20 Impact factor: 10.122
Authors: Wang Zhancheng; Ji Wenhui; Jiang Yun; Wang Lingli; Huang Huijun; Shen Yan; Li Jin Journal: Medicine (Baltimore) Date: 2019-06 Impact factor: 1.817