Ni-catalyzed construction of C-P bonds from electron-deficient phenols via the in situ aryl C-O activation by PyBroP.

The C-P bond forming reaction using electron-deficient phenol substrates was considerably challenging. Herein, we present a new protocol that allows for one-pot construction of C-P bonds via the cross-coupling of phenols and phosphine oxide or phosphite in the presence of a nickel catalyst.